TABLEĀ 3

MicroRNAs modulated by valproic acid

TaqMan targetmiRBase numberFold changep-value by t-testCorrected p-value
hsa-miR-589hsa-miR-589*441.317350.0000150.005305
hsa-miR-575hsa-miR-5750.017870.0001750.031945
hsa-miR-200a*hsa-miR-200a*4.236660.0010850.112437
hsa-miR-345NA5.416710.0012320.112437
hsa-miR-124ahsa-miR-1240.277560.0023180.120889
hsa-miR-16hsa-miR-160.382240.0018080.120889
hsa-miR-616hsa-miR-616*0.063160.0021450.120889
hsa-miR-182*hsa-miR-182*0.286580.0034720.154357
hsa-miR-376a*NA0.044610.0042290.154357
hsa-miR-130bhsa-miR-130b0.460740.0053760.165957
hsa-miR-9hsa-miR-93.511740.0054560.165957
hsa-let-7ahsa-let-7a3.527770.0082000.201666
hsa-miR-106bhsa-miR-106b0.490530.0082880.201666
hsa-miR-142-3phsa-miR-142-3p4.822120.0078630.201666
hsa-miR-200chsa-miR-200c2.307330.0106240.212291
hsa-miR-29chsa-miR-29c0.439670.0116320.212291
hsa-miR-564hsa-miR-5644.749890.0115710.212291
hsa-miR-9*hsa-miR-9*0.432870.0108190.212291
hsa-miR-99bhsa-miR-99b0.496260.0114790.212291
hsa-miR-324-5phsa-miR-324-5p0.495510.0143150.237493
hsa-let-7ghsa-let-7g2.605560.0174170.264876
hsa-miR-181bhsa-miR-181b2.163300.0190210.272956
hsa-miR-594NA0.402640.0194430.272956
hsa-let-7dhsa-let-7d2.828680.0224290.303208
hsa-miR-572hsa-miR-5720.307440.0297940.362498
hsa-miR-335hsa-miR-3350.380500.0388490.386740
hsa-miR-565NA0.404630.0449280.395449
hsa-miR-99ahsa-miR-99a0.452900.0496590.421521
  • Expression of microRNAs was determined by TaqMan Low Density Array in H526 cells treated with valproic acid+VAC or VAC alone. For fold changes <0.5 or >2, the uncorrected p-value was <0.05 (common microRNAs when normalised to RNU44 and RNU48). NA: not applicable; VAC: mafosfamide, doxorubicin and vindesine.