Summary demographic and washout data for control and cystic fibrosis subjects who completed repeat wash-out measurements with both an open circuit wash-in and a modified closed circuit wash-in

Healthy volunteersCystic fibrosisp-value for healthy volunteers versus cystic fibrosis
Subjects n1219
Age years34.2±10.430.2±6.20.2
Males/females n/n1/1113/60.002
FEV1 z-score−0.5±1.0−2.3±1.30.0006
FVC z-score−0.1±1.2−1.2±1.20.03
FEV1 % predicted−94.7±12.571.9±15.90.0005
LCI open6.5±0.510.9±2.6<0.0001
LCI closed6.4±0.510.8±2.2<0.0001
p-value for open versus closed0.20.2
FRC open L2.32±0.702.66±0.810.2
FRC closed L2.34±0.672.75±0.800.2
p-value for open versus closed0.60.1
  • Data are presented as mean±sd unless otherwise stated. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; LCI: lung clearance index; FRC: functional residual capacity.