TABLE 1

Subject demographics and baseline lung function for subjects in the study

NormalAsthmaCOPDp-value
Subjects n202218
 Males8812
Age years32±1059±1766±9<0.001
Height cm169±11164±10170±60.1
Weight kg71±1576±1873±140.6
Spirometry
 FEV1 % predicted100±1467±2461±25<0.001
 FVC % predicted100±1587±1996±230.08
 FEV1/FVC %84±661±1447±11<0.001
FOT
Rrs at 5 Hz hPa·s ·L−12.6 (2.3–3.5)5.2 (4.2–6.9)4.7 (4.0–6.8)<0.001
Rrs at 5 Hz % predicted100 (83–125)170 (128–196)194 (151–253)<0.001
Xrs at 5 Hz hPa·s·L−1−1.1 (−1.2–−0.8)−2.3 (−5.0–−1.6)−3.3 (−6.0–−1.6)<0.001
Xrs at 5 Hz % predicted115 (78–135)185 (133–307)320 (144–530)<0.001
 Respiratory rate min−113.1±4.214.5±3.816.2±3.50.06
  • Data are shown as mean±sd or median (interquartile range), unless otherwise stated. Forced oscillation technique (FOT) parameters are reported for the default duration setting of 16 s. p-values were obtained from a one-way ANOVA or Kruskal–Wallis (non-parametric ANOVA). FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; Rrs: total respiratory system resistance; Xrs: total respiratory system reactance.