Functional annotation of the gene clusters

ClusterGenes in clusterFunction derived from Pathway Enrichment
and Gene Ontology analyses
Gene list
06TLR signalling: unfolded protein responseDNAJB1, DNAJC5B, HSPA1A, HSPB1, SAA1, TLR2
102TLR signallingCD86, CXCL9
16Chemokines: signallingCCL17, CCL22, CCL4, CCR1, CXCL13, CXCL5
73Chemokines: activityCCL2, CCL3, CCL7
112Chemokines: NOD-like receptor signallingCXCL1, CXCL2
25Muscle contractionACTN2, MYH6, MYL1, TCAP, TNNI3
35IntegrinsCD14, ITGAM, ITGAX, ITGB2, SPON2
44Circadian clockARNTL, DBP, NR1D1, PER1
53Osteoclast differentiationCLEC5A, TREM2, TYROBP
63Interleukins: FC-epsilon receptor I signallingFCER1G, FCGR2B, IL12B
142InterleukinsIL1R2, IL1RN
83p53 pathwayIGF1, IGFBP3, IGFBP6
122Class I MHC mediated antigen processing and presentationCYBA, NCF4
132Immune response (complement pathway)C1QA, C1QB
152Glutathione metabolismGCLC, GCLM
162Heterotrimeric G-protein signalling pathway-Gq alpha and Go alpha mediated pathwayRGS1, RGS16
  • There were no pathways or processes significantly represented by cluster 9. TLR: Toll-like receptor; NOD: nucleotide-binding oligomerisation domain; MHC: major histocompatibility complex.