TABLE 4

Multivariable multinomial logistic regression analysis for risk factors associated with tuberculosis cases in molecular clusters of different sizes in London (2010–2014), adjusted for random effects of Lower Layer Super Output Area (LSOA)

Cases in cluster n
23–20>20
Sex
 Female111
 Male0.98 (0.83–1.16)1.08 (0.95–1.23)1.14 (0.94–1.38)
Age group years
 0–141.15 (0.65–2.02)1.18 (0.76–1.83)1.29 (0.75–2.22)
 15–44111
 45–641.13 (0.92–1.39)0.97 (0.82–1.15)0.82 (0.64–1.04)
 ≥650.68 (0.50–0.93)0.71 (0.56–0.90)0.52 (0.35–0.78)
Ethnic group
 White111
 Black-Caribbean2.1 (1.25–3.55)3.13 (2.08–4.71)3.64 (2.23–5.94)
 Black-African1.35 (0.99–1.86)1.86 (1.46–2.38)2.09 (1.49–2.91)
 Black-Other1.88 (0.92–3.84)1.92 (1.07–3.45)2.29 (1.13–4.66)
 Indian0.95 (0.70–1.30)1.02 (0.80–1.30)0.78 (0.55–1.11)
 Pakistani1.08 (0.75–1.55)1.02 (0.76–1.36)1.51 (1.02–2.24)
 Bangladeshi0.60 (0.38–0.94)0.53 (0.37–0.76)0.26 (0.13–0.50)
 Chinese0.78 (0.37–1.64)0.78 (0.44–1.40)0.63 (0.24–1.68)
 Mixed/other1.12 (0.81–1.54)1.11 (0.86–1.43)0.89 (0.61–1.29)
Place of birth
 Non-UK111
 UK1.45 (1.12–1.87)2.13 (1.75–2.58)2.93 (2.28–3.77)
Occupation
 Other111
 None1.04 (0.85–1.27)0.96 (0.82–1.12)1.18 (0.94–1.49)
 Education1.04 (0.82–1.31)1.04 (0.87–1.24)1.31 (1.01–1.70)
 Healthcare1.00 (0.69–1.45)0.82 (0.60–1.11)0.47 (0.25–0.87)
Pulmonary disease
 No111
 Yes1.46 (1.24–1.72)1.48 (1.30–1.68)1.47 (1.21–1.79)
Drug resistance#
 No111
 Yes1.25 (0.96–1.61)0.82 (0.65–1.03)1.75 (1.34–2.28)
Risk factor count
 0111
 10.83 (0.59–1.15)1.12 (0.88–1.42)1.36 (0.99–1.87)
 21.00 (0.53–1.89)1.59 (1.00–2.52)2.46 (1.45–4.18)
 30.86 (0.35–2.12)1.28 (0.67–2.45)3.75 (1.96–7.16)
 44.35 (0.39–48.50)4.13 (0.45–37.58)16.64 (1.98–139.88)
IMD quintile+0.98 (0.91–1.04)1.00 (0.95–1.06)0.90 (0.83–0.97)
  • Data are presented as adjusted odds ratio (95% CI). IMD: index of multiple deprivation. #: resistance to any first-line antibiotic; : cumulative number of social risk factors (history of homelessness, illicit drug use, alcohol misuse, imprisonment) reported by each case; +: IMD quintile of LSOA within London (lowest is most deprived), included as a continuous variable in multilevel model accounting for random effects of LSOA.