Characteristics of ongoing studies

Study name or titleChief investigatorStudy period (start and end dates) (country)Study designParticipantsInterventionComparisonOutcomes
Pulmonary Rehabilitation and ACTIvity after COPD Exacerbations: the PRACTICE trial: a randomised trial [24]R. HughesJanuary 2015 to December 2016 (UK)Parallel group, randomised pilot 2×2 trial76 participants with clinically identified exacerbation of diagnosed COPD1) In-hospital exercise training followed by in-home post-discharge early rehabilitation; 2) standard in-hospital care followed by in-home post-discharge early rehabilitation1) In-hospital exercise training followed by standard discharge care; 2) standard in-hospital care followed by standard dischargeSubsequent uptake, adherence and completion of group-based community pulmonary rehabilitation
Video to Increase RehabiliTation Uptake following hospitalised Exacerbations of COPD (VIRTUE): a randomised controlled trial [25]W. ManJanuary 2015 to January 2017 (UK)Parallel group, randomised trial200 adults aged >40 years diagnosed with COPD, admitted to hospital with acute exacerbation of COPD and fit enough to take part in pulmonary rehabilitationParticipants will be asked to watch a 5-min patient-designed video promoting early pulmonary rehabilitation plus usual careUsual care: provided with standard verbal information and an A5 patient information leaflet about early pulmonary rehabilitationUptake, adherence and completion of post-exacerbation pulmonary rehabilitation
A tailored, psychological intervention for mild to moderate anxiety or depression in people with COPD: Tailored intervention for ANxiety and DEpression Management in COPD (TANDEM) [26]S. TaylorApril 2016 to January 2021 (UK)Three-phase study (phase I: preparation; phase II: pilot randomised controlled trial; phase III: a fully powered individually randomised controlled trial)Adults with moderate–severe COPD with mild–moderate comorbid anxiety or depression and eligible for attendance at their local pulmonary rehabilitation; phase II: 45 participants; phase III: 430 participantsTailored, one-to-one psychological intervention combined with practical problem-solving components based on: Self-management Programme of Activity Coping and Education (SPACE) and The Lung Manual, a nurse-led intervention based on cognitive behavioural principles and self-management, and developed to address mood disorders of anxiety in COPD; this psychological intervention links into, and interdigitates with, usual pulmonary rehabilitation, but is independent of itUsual care: standard pulmonary rehabilitation without interdigitating psychological interventionUptake and completion of pulmonary rehabilitation (to be informed by the pre-pilot and pilot studies)
  • COPD: chronic obstructive pulmonary disease.