TABLE 1

Top 10 up- and downregulated genes following Calogen treatment of PMA/THP-1 cells

Fold changeGene symbolDescriptionDirectionp-value (corr)
971IL8Homo sapiens interleukin 8 (IL8), mRNA [NM_000584] – a neutrophil chemotactic cytokine↑3.07×10−10
86ANGPTL4Homo sapiens angiopoietin-like 4 (ANGPTL4), transcript variant 1, mRNA [NM_139314] – modulates glucose homeostasis and lipid metabolism↑2.80×10−7
63CXCL3Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA [NM_002090] – neutrophil chemoattractant↑9.63×10−12
56FBXW10Homo sapiens F-box and WD repeat domain containing 10 (FBXW10), mRNA [NM_031456] – a protein ubiquitin ligase↑4.39×10−8
46CCL20Homo sapiens chemokine (C-C motif) ligand 20 (CCL20), transcript variant 1, mRNA [NM_004591] – involved in inflammation, lymphocyte chemotactic activity↑5.13×10−5
45GPR56Homo sapiens G protein-coupled receptor 56 (GPR56), transcript variant 3, mRNA [NM_201525]↑1.95×10−5
42ADORA2AHomo sapiens adenosine A2a receptor (ADORA2A), mRNA [NM_000675] – a GPCR with multiple roles, implicated in inflammatory diseases↑7.78×10−8
40CCL4Homo sapiens chemokine (C-C motif) ligand 4 (CCL4), transcript variant 1, mRNA [NM_002984] – mitogen-inducible monokine with inflammatory functions↑5.43×10−7
39IL8Interleukin 8 [Source: HGNC Symbol; Acc:6025] [ENST00000401931] – a neutrophil chemotactic cytokine↑6.49×10−11
38CCL4Homo sapiens chemokine (C-C motif) ligand 4 (CCL4), transcript variant 1, mRNA [NM_002984] – mitogen-inducible monokine with inflammatory functions↑5.34×10−7
108.3XLOC_000604UI-E-EJ1-ajw-b-14-0-UI.r1 UI-E-EJ1 Homo sapiens cDNA clone UI-E-EJ1-ajw-b-14-0-UI 5′, mRNA sequence [BQ188485] – unknown↓8.28×10−9
78.5MS4A6AHomo sapiens membrane-spanning 4-domains, subfamily A, member 6A (MS4A6A), transcript variant 2, mRNA [NM_022349] – may be involved in signal transduction↓2.47×10−7
72.0GPA33Homo sapiens glycoprotein A33 (transmembrane) (GPA33), mRNA [NM_005814] – possibly involved in cell–cell recognition↓6.52×10−7
71.0MS4A6AHomo sapiens membrane-spanning 4-domains, subfamily A, member 6A (MS4A6A), transcript variant 1, mRNA [NM_152852] – may be involved in signal transduction↓3.97×10−6
55.2MRVI1Homo sapiens murine retrovirus integration site 1 homologue (MRVI1), transcript variant 2, mRNA [NM_130385] – multiple roles including regulation of IP3-induced calcium release↓4.06×10−12
42.4CX3CR1Homo sapiens chemokine (C-X3-C motif) receptor 1 (CX3CR1), transcript variant 4, mRNA [NM_001337] – CX3C receptor involved in its adhesion and migratory functions↓5.43×10−10
40.7GPR34Homo sapiens G protein-coupled receptor 34 (GPR34), transcript variant 4, mRNA [NM_001097579] – exact function unknown↓9.87×10−12
38.5ENHOHomo sapiens energy homeostasis associated (ENHO), mRNA [NM_198573] – role in glucose homeostasis and lipid metabolism↓2.52×10−6
30.5LOC100505633Homo sapiens uncharacterised LOC100505633, non-coding RNA [NR_038849] – unknown function↓9.37×10−8
29.8MNDAHomo sapiens myeloid cell nuclear differentiation antigen (MNDA), mRNA [NM_002432] – may regulate transcription in myeloid cells↓8.80×10−8