Patient characteristics and clinical data

Subjects n59
Males54 (91.5)
Age years71.7±8.2
Smoking history49 (86.0)
FVC before AE % predicted71.0±21.9
DLCO before AE % predicted37.0±17.3
Treatment before AE
 LTOT23 (39.0)
 Corticosteroids20 (33.9)
 Immunosuppressive agents10 (16.9)
WBC µL−110 490±4150
D-dimer µg·mL−15.1±6.3
CRP mg·dL−16.5±6.4
LDH IU·L−1380±226
KL-6 U·mL−11763±1278
P/F<20026 (47.3)
BAL performed11 (18.6)
Treatment of AE
 High-dose corticosteroids59 (100)
 Antibiotics58 (98.3)
 Immunosuppressive agents30 (50.8)
 Noninvasive ventilation14 (23.7)
180-day mortality %59.2

The data are presented as mean±sd or n (%), unless otherwise indicated. FVC: forced vital capacity; AE: acute exacerbation; DLCO: diffusing capacity of the lung for carbon monoxide; LTOT: long-term oxygen therapy; WBC: white blood cell; CRP: C-reactive protein; LDH: lactate dehydrogenase; KL-6: Krebs von den Lungen-6; P/F: the ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen; BAL: bronchoalveolar lavage.