TABLE 4

Risk of cancer when family members were diagnosed with histology-specific lung cancer and risk of histology-specific lung cancer when family members were diagnosed with discordant cancer

Cancer site and histological typeNegative family historyOne lung cancer case in the familyAt least two lung cancer cases in the familyTrend test p-value
CasesRR (95% CI)CasesRR (95% CI)
Risk of discordant cancer
 Anus
  Adenocarcinoma1062261.60# (1.08–2.36)00.0284
  SCC1067211.27 (0.84–1.94)00.2732
  Small cell108351.21 (0.51–2.84)00.6734
  Large cell108530.71 (0.24–2.14)00.5231
 Connective tissue
  Adenocarcinoma3697711.48# (1.15–1.91)23.68 (0.82–16.61)0.0022
  SCC3730400.89 (0.62–1.30)00.5455
  Small cell3756141.12 (0.64–1.94)00.6982
  Large cell3758120.93 (0.51–1.73)00.8255
Risk of lung cancer
 Anus
  Adenocarcinoma9660271.77# (1.10–2.84)00.0307
  SCC404060.95 (0.35­- 2.62)00.9230
  Small cell253441.00 (0.32–3.11)00.9986
  Large cell300571.49 (0.45–4.88)00.5399
 Connective tissue
  Adenocarcinoma9619681.40# (1.01–1.94)00.0575
  SCC4027190.94 (0.54–1.64)00.8300
  Small cell2518201.58# (1.04–2.40)00.0482
  Large cell2989231.53# (1.02–2.29)00.0542

RR: relative risk; SCC: squamous cell carcinoma. #: significantly increased RR at the two-sided 5% level; : statistically significant.