Patient characteristics
| Patients without a DNR order | Patients with a DNR order | p-value | ||
| Having a DNR order at baseline | Receiving a DNR order during follow-up | |||
| Patients n | 345 | 17 | 177 | |
| Demographic | ||||
| Age years | 72.6±8.8 | 79.3±6.0 | 76.6±8.3 | <0.0001 |
| Female | 91 (26) | 5 (29) | 40 (23) | 0.565 |
| BMI kg·m−2 | 25.0 (22.4–28.4) | 24.5 (18.8–26.3) | 23.4 (20.6–27.4) | 0.010 |
| Obese | 69 (20) | 3 (18) | 26 (15) | 0.309 |
| Disease severity | ||||
| FEV1 L | 1.4 (1.1–1.8) | 0.9 (0.6–1.1) | 1.2 (0.9–1.5) | <0.0001 |
| FEV1 % pred | 55.0 (41.0–67.0) | 32.0 (21.0–46.0) | 42.0 (33.5–54.0) | <0.0001 |
| DLCO L | 4.4 (3.3–5.6) | 2.8 (2.3–3.2) | 3.6 (2.7–4.5) | <0.0001 |
| DLCO % pred | 53.0 (40.0–67.0) | 37.0 (28.0–39.5) | 45.0 (33.0–55.0) | <0.0001 |
| MRCQ score 1–5 | 3 (2–3) | 4 (3–4) | 3 (2–4) | <0.0001 |
| Chronic oxygen dependency | 21 (6) | 8 (47) | 47 (27) | <0.0001 |
| Previous mechanical ventilation | 11 (3) | 2 (12) | 20 (11) | 0.001 |
| DNR order | ||||
| 0/1a/1b/2/3 | 3/6/8/0/0 (18/35/47/0/0) | 19/41/69/46/2 (11/23/39/26/1) | <0.0001 | |
| Time to first DNR order days | −230.0 (−409.5–−53.5) | 945.0 (386.5–1601.0) | <0.0001 | |
| Location | 0.707 | |||
| Hospital ward | 13 (76) | 122 (69) | ||
| Consultation | 0 (0) | 24 (14) | ||
| ER | 2 (12) | 15 (8) | ||
| ICU | 2 (12) | 15 (8) | ||
| RT | 0 (0) | 1 (1) | ||
| Outcome | ||||
| Mortality | 94 (27) | 14 (82) | 135 (76) | <0.0001 |
| Follow-up time days | 1935.0 (1290.0–2448.0) | 528.0 (136.5–901.0) | 1322.0 (721.0–2018.5) | <0.0001 |
| Location | 0.002 | |||
| Hospital ward | 9 (10) | 10 (72) | 55 (41) | |
| ER | 2 (2) | 0 (0) | 6 (5) | |
| ICU | 7 (7) | 2 (14) | 11 (8) | |
| Palliative care unit | 1 (1) | 0 (0) | 14 (10) | |
| Other | 75 (80) | 2 (14) | 49 (36) | |
| Cause of death | <0.0001 | |||
| Respiratory | 4 (4) | 10 (72) | 56 (42) | |
| Cardiac | 5 (6) | 1 (7) | 6 (4) | |
| Cancer | 3 (3) | 0 (0) | 20 (15) | |
| Stroke | 1 (1) | 0 (0) | 3 (2) | |
| Other | 4 (4) | 0 (0) | 12 (9) | |
| Unknown | 77 (82) | 3 (21) | 38 (28) | |
| Time between first DNR and death days | 690.5 (255.25–872.5) | 118.0 (23.0–364.0) | <0.0001 | |
Data are presented as n (%), mean±sd or median (interquartile range), unless otherwise stated. DNR: do-not-resuscitate; BMI: body mass index; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide; MRCQ: Medical Research Council Questionnaire; ER: emergency room; ICU: intensive care unit; RT: radiotherapy.