TABLE 2

Patient characteristics

Patients without a DNR orderPatients with a DNR orderp-value
Having a DNR order at baselineReceiving a DNR order during follow-up
Patients n34517177
Demographic
 Age years72.6±8.879.3±6.076.6±8.3<0.0001
 Female91 (26)5 (29)40 (23)0.565
 BMI kg·m−225.0 (22.4–28.4)24.5 (18.8–26.3)23.4 (20.6–27.4)0.010
 Obese69 (20)3 (18)26 (15)0.309
Disease severity
 FEV1 L1.4 (1.1–1.8)0.9 (0.6–1.1)1.2 (0.9–1.5)<0.0001
 FEV1 % pred55.0 (41.0–67.0)32.0 (21.0–46.0)42.0 (33.5–54.0)<0.0001
DLCO L4.4 (3.3–5.6)2.8 (2.3–3.2)3.6 (2.7–4.5)<0.0001
DLCO % pred53.0 (40.0–67.0)37.0 (28.0–39.5)45.0 (33.0–55.0)<0.0001
 MRCQ score 1–53 (2–3)4 (3–4)3 (2–4)<0.0001
 Chronic oxygen dependency21 (6)8 (47)47 (27)<0.0001
 Previous mechanical ventilation11 (3)2 (12)20 (11)0.001
DNR order
 0/1a/1b/2/33/6/8/0/0 (18/35/47/0/0)19/41/69/46/2 (11/23/39/26/1)<0.0001
 Time to first DNR order days−230.0 (−409.5–−53.5)945.0 (386.5–1601.0)<0.0001
 Location0.707
    Hospital ward13 (76)122 (69)
    Consultation0 (0)24 (14)
    ER2 (12)15 (8)
    ICU2 (12)15 (8)
    RT0 (0)1 (1)
Outcome
 Mortality94 (27)14 (82)135 (76)<0.0001
 Follow-up time days1935.0 (1290.0–2448.0)528.0 (136.5–901.0)1322.0 (721.0–2018.5)<0.0001
 Location0.002
    Hospital ward9 (10)10 (72)55 (41)
    ER2 (2)0 (0)6 (5)
    ICU7 (7)2 (14)11 (8)
    Palliative care unit1 (1)0 (0)14 (10)
    Other75 (80)2 (14)49 (36)
 Cause of death<0.0001
    Respiratory4 (4)10 (72)56 (42)
    Cardiac5 (6)1 (7)6 (4)
    Cancer3 (3)0 (0)20 (15)
    Stroke1 (1)0 (0)3 (2)
    Other4 (4)0 (0)12 (9)
    Unknown77 (82)3 (21)38 (28)
 Time between first DNR and death days690.5 (255.25–872.5)118.0 (23.0–364.0)<0.0001

Data are presented as n (%), mean±sd or median (interquartile range), unless otherwise stated. DNR: do-not-resuscitate; BMI: body mass index; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide; MRCQ: Medical Research Council Questionnaire; ER: emergency room; ICU: intensive care unit; RT: radiotherapy.