Post-immunisation immunity to influenza virus strains in pregnant study subjects
| Observation time-point | Group I Agrippal S1# | Group II Grippol Plus¶ | ||||
| A(H1N1, California 7, 2009) | A(H3N2, Victoria) | B(Brisbane) | A(H1N1, California 7, 2009) | A(H3N2, Victoria) | B(Brisbane) | |
| Seroprotection level+ % | ||||||
| Baseline (gestation weeks 13–30) | 16.2* | 18.9 | 48.7** | 9.5 | 19.0 | 23.8 |
| 1 month post immunisation | 75.6 | 64.8* | 94.5 | 72.5 | 87.5 | 90.0 |
| 3 months post immunisation | 70.2 | 62.1* | 94.5 | 75.6 | 86.4 | 89.1 |
| 5–6 months post immunisation (day 2 or 3 post partum) | 67.5 | 62.1* | 91.9* | 64.8 | 78.3 | 75.6 |
| 8–9 months post immunisation (3rd month post partum) | 62.1 | 51.3* | 72.9 | 54.2 | 71.4 | 74.2 |
| Antibody geometric mean titre ±sd | ||||||
| Baseline (gestation weeks 13–30) | 7.9±0.2 | 8.7±0.3 | 22.9±0.2* | 8.9±0.2 | 8.5±0.2 | 14.8±0.3 |
| 1 month post immunisation | 57.9±0.4 | 41.1±0.4* | 143.2±0.2* | 50.4±0.3 | 78.2±0.3 | 115.8±0.31 |
| 3 months post immunisation | 51.6±0.4 | 30.3±0.4* | 108.5±0.2* | 49.2±0.3 | 56.6±0.3 | 81.8±0.3 |
| 5–6 months post immunisation (day 2 or 3 post partum) | 42.4±0.4 | 34.8±0.7* | 85.7±0.3* | 38.2±0.2 | 45.9±0.2 | 54.0±0.3 |
| 8–9 months post immunisation (3rd month post partum) | 27.3±0.4ƒ | 23.8±0.6ƒ | 47.6±0.4ƒƒ | 30.3±0.3 | 30.3±0.2 | 44.9±0.2 |
| Seroconversion level§ % | ||||||
| 1 month post immunisation | 62.1 | 51.3* | 64.8 | 57.1 | 71.4 | 64.2 |
| Seroconversion factor## | ||||||
| 1 month post immunisation | 7.2 | 4.7* | 6.2 | 5.7 | 9.2 | 7.8 |
#: n=37; ¶: n=42; +: proportion of immunised patients with antibody titres ≥1:40 must be ≥70%; §: must be ≥40%; ##: must be ≥2.5. *: p<0.05 for differences between the compared groups; **: p<0.01 for differences between the compared groups; ƒ: p<0.05 for differences between 1 month post immunisation and 8–9 months post immunisation inside the reference group; ƒƒ: p<0.01 for differences between 1 month post immunisation and 8–9 months post immunisation inside the reference group.