Demographic, pulmonary function and gas exchange parameters in noninvasive ventilation (NIV) group and no-NIV group

NIVNo NIVp-value
Age years64.05±9.1166.05±10.270.373
Spinal/bulbar ALS onset81/3913/70.826
Time from ALS onset to NIV months22.30±10.5123.35±10.270.680
BMI kg·m−226.15±4.2324.28±3.560.055
No or moderate/severe bulbar dysfunction105/1514/60.052
FVC L1.45±0.801.24±1.010.387
FVC % predicted49.28±23.0544.75±26.850.484
MIC L1.96±0.951.58±1.210.240
PCF L·s−13.48±1.692.88±1.490.114
PCFMIC L·s−14.07±1.943.22±1.880.108
PCFMI−E L·s−13.70±1.073.26±0.640.090
PImax cmH2O−42.37±22.82−35.33±21.900.220
PEmax cmH2O65.54±42.2858.72±40.950.519
PaO2 mmHg74.32±11.9581.41±11.340.027
PaCO2 mmHg50.34±8.6845.52±7.420.023
HCO3 mmol·L−129.02±3.0920.70±3.650.740

Data are presented as n or mean±sd unless otherwise stated. ALS: amyotrophic lateral sclerosis; ALSFRS-R: revised amyotrophic lateral sclerosis functional rating scale; BMI: body mass index; NBS: Norris scale bulbar subscore; FVC: forced vital capacity; MIC: maximum insufflation capacity; PCF: peak cough flow; PCFMIC: manually assisted peak cough flow; PCFMI-E: mechanically assisted peak cough flow; PImax: maximum inspiratory pressure; PEmax: maximum expiratory pressure; PaO2: arterial oxygen tension; PaCO2: arterial carbon dioxide tension; %sleepSpO2<90: time spent with oxygen saturation measured by pulse oximetry (SpO2) <90%; SpO2mean: mean SpO2; SpO2min: minimum SpO2.