TABLE 2

Baseline right heart catheter and noninvasive variables

Total derivation cohortmPAP <25 mmHgmPAP 25–34 mmHgmPAP ≥35 mmHgp-value
Subjects210467985 
Age years61±1163±1164±1158±120.004
Male %555254560.9
ILD diagnosis  
 CTD59 (28)15 (25)21 (36)23 (39)0.7
 Sarcoidosis43 (20)4 (9)14 (33)25 (58)0.01
 IPF62 (29)18 (29)28 (45)16 (26)0.02
 CHP16 (8)6 (38)2 (12)8 (50)0.1
 NSIP16 (8)2 (12)8 (50)6 (38)0.5
 Other ILD14 (7)1 (7)6 (43)7 (50)0.4
Right heart catheter  
 mPAP mmHg33±1120±429±343±7<0.001
 PVR Wood units6.0±3.62.6±1.54.6±1.88.8±3.8<0.001
 Cardiac output L·min−1·m−24.3±1.34.8±1.34.1±1.34.1±1.20.02
 PCWP mmHg10±58±510±511±50.008
BNP ng·L−1102 (44–266)48 (30–72)90 (42–141)241 (105–436)<0.001
Pulmonary function tests  
 FEV1 L1.6±0.61.6±0.61.5±0.51.6±0.60.9
 FEV1 % pred58±1862±2157±1757±170.2
 FVC L2.0±0.82.0±0.81.9±0.72.2±0.90.2
 FVC % pred60±2061±2259 ±1862±220.7
TLCO % pred25±1028±1025±924 ±100.04
KCO % pred52±1759±1854±1648±16<0.001
PaO2 kPa7.9±1.98.9±1.98.1±1.97.1±1.7<0.001
CT scan  
 ILD extent <20%/>20%14/8615/8519/819/910.2

Data are presented as n, mean±sd, n (%) or median (interquartile range), unless otherwise stated. mPAP: mean pulmonary pressure at right heart catheterisation; ILD: interstitial lung disease; CTD: connective tissue disease; IPF idiopathic pulmonary fibrosis; CHP: chronic hypersensitivity pneumonitis; NSIP: nonspecific interstitial pneumonia; PVR: pulmonary vascular resistance; PCWP: pulmonary capillary wedge pressure; BNP: brain natriuretic peptide; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLCO: transfer factor of the lung for carbon monoxide; KCO: transfer coefficient of the lung for carbon monoxide; PaO2 : arterial oxygen tension (by capillary blood gas analysis); CT: computed tomography.