Summary of the age-normalised galactosylation status (logarithmically transformed ratio between the main agalactosylated form (FA2) and the main digalactosylated form (FA2G2)) for each subgroup as well as false discovery rate-corrected p-values (n=506) and area under the curve (AUC) values when comparing the individuals with and without lung disease
| IgG4 | IgG1 | IgG2/(3) | |
| log(FA2/FA2G2) mean±sd | |||
| H | 0.22±0.24 | −0.08±0.19 | 0.19±0.21 |
| RA# | 0.37±0.26 | 0.18±0.26 | 0.33±0.21 |
| LS | 0.42±0.33 | 0.10±0.24 | 0.31±0.35 |
| Non-LS | 0.52±0.22 | 0.17±0.28 | 0.44±0.26 |
| SA | 0.73±0.32 | 0.41±0.35 | 0.73±0.31 |
| p-value | |||
| H versus | |||
| LS+non-LS+SA | 3.6×10−4 | 5.3×10−4 | 1.1×10−3 |
| Non-LS+SA | 2.7×10−4 | 2.8×10−4 | 9.8×10−4 |
| LS | 1.3×10−1 | 1.4×10−1 | 4.7×10−1 |
| Non-LS | 6.2×10−3 | 5.3×10−2 | 5.6×10−2 |
| SA | 2.7×10−4 | 2.6×10−4 | 2.6×10−4 |
| H+RA versus | |||
| LS+non-LS+SA | 9.2×10−4 | 2.9×10−2 | 1.2×10−3 |
| Non-LS+SA | 2.6×10−4 | 9.2×10−3 | 2.6×10−4 |
| LS | 3.2×10−1 | 7.1×10−1 | 7.0×10−1 |
| Non-LS | 3.1×10−2 | 3.6×10−1 | 1.0×10−1 |
| SA | 2.0×10−4 | 1.9×10−3 | 5.9×10−5 |
| RA versus | |||
| LS+non-LS+SA | 7.9×10−2 | 5.2×10−1 | 1.2×10−1 |
| Non-LS+SA | 2.2×10−2 | 3.3×10−1 | 2.0×10−2 |
| LS | 7.5×10−1 | 5.6×10−1 | 9.1×10−1 |
| Non-LS | 2.6×10−1 | 9.6×10−1 | 4.2×10−1 |
| SA | 1.0×10−2 | 1.2×10−1 | 2.4×10−3 |
| AUC mean±se | |||
| H versus | |||
| LS+non-LS+SA | 85±6% | 82±6% | 80±6% |
| Non-LS+SA | 90±5% | 85±6% | 88±5% |
| LS | 70±11% | 70±11% | 58±12% |
| Non-LS | 87±7% | 80±9% | 78±10% |
| SA | 91±5% | 88±6% | 94±4% |
| H+RA versus | |||
| LS+non-LS+SA | 78±6% | 70±6% | 75±6% |
| Non-LS+SA | 83±6% | 73±75% | 83±5% |
| LS | 60±10% | 58±10% | 51±11% |
| Non-LS | 76±8% | 62±10% | 70±9% |
| SA | 87±6% | 80±7% | 90±5% |
| RA versus | |||
| LS+non-LS+SA | 72±7% | 59±9% | 69±7% |
| Non-LS+SA | 77±7% | 62±9% | 78±7% |
| LS | 50±12% | 53±12% | 59±12% |
| Non-LS | 67±11% | 55±12% | 62±12% |
| SA | 83±7% | 73±9% | 87±6% |
For the Löfgren's syndrome (LS) patient measured twice (1 year in between sampling dates), the mean was used as data point. H: healthy controls; RA: rheumatoid arthritis; SA: severe asthma. #: information obtained from published data [13].