Peri- and postoperative characteristics in the bosentan monotherapy and bosentan/metformin combination therapy groups
| Bosentan | Bosentan/metformin | |
| Patients undergoing operation n (%) | 40 (83.3%) | 38 (86.4%) |
| CPB time min | 48±13 | 56±13 |
| Cross-clamping time min | 26±9 | 24±8 |
| Hospital mortality | 0 (0%) | 0 (0%) |
| Mechanical ventilation time h | 18±8 | 16±6 |
| Length of ICU stay h | 36±9 | 28±6 |
| Length of hospital stay days | 12±6 | 10±4 |
| Infection | 4 (10%) | 6 (15.8%) |
| Reintubation | 3 (7.5%) | 2 (5.3%) |
| Tracheotomy | 1 (2.5%) | 0 (0%) |
| Arrhythmia | 12 (30%) | 9 (23.7%) |
| Neurologic complication | 2 (5%) | 3 (7.9%) |
Data are presented as mean±sd or n (%). CPB: cardiopulmonary bypass; ICU: intensive care unit.