TABLE 3

Variables relating to the impact of disease, treatment and healthcare utilisation to be collected in NOVELTY

Variable	Collection^#
	Baseline		Every 3 months	Yearly
	Physician-reported	Patient-reported	Patient-reported	Physician-reported	Patient-reported
Impact on daily activity and quality of life
HRQoL
SGRQ		✓			✓
EQ-5D-5L		✓	✓		✓
WPAI		✓			✓
Treatment(s) during previous 12 months
Asthma/COPD treatments	✓	✓	✓	✓	✓
Treatment duration and frequency	✓	✓	✓	✓	✓
Posology	✓			✓
Patterns of use and treatment adherence for asthma/COPD treatments		✓	✓	✓	✓
Burden of out-of-pocket asthma/COPD treatment expenses^¶		✓			✓
Reasons for switching/ interruptions/discontinuations of each asthma or COPD treatment		✓	✓	✓	✓
Asthma/COPD treatment satisfaction		✓	✓		✓
Concomitant medications	✓			✓
Healthcare utilisation during previous 12 months (eCRF) or previous 3 months (PROs)
Medications, emergency and nonemergency physician visits	✓	✓	✓	✓	✓
Respiratory and nonrespiratory hospitalisations	✓	✓	✓	✓	✓
Out-of-pocket expenses (USA only)		✓			✓
Exacerbations, emergency department visits, hospitalisations, days in ICU	✓	✓	✓	✓	✓
Tests performed during exacerbations	✓			✓

COPD: chronic obstructive pulmonary disease; eCRF: electronic case report form; EQ-5D-5L: EuroQol 5 dimensions 5 levels health questionnaire; HRQoL: health-related quality of life; ICU: intensive care unit; NOVELTY: a NOVEL observational longiTudinal studY; PRO: patient-reported outcome; SGRQ: St George's Respiratory Questionnaire; WPAI: work productivity and activity impairment. ^#: baseline and yearly data will be collected from healthcare professionals during clinical visits, while 3-monthly data will be collected directly from the patient via follow up by web-based platform or telephone, and in conjunction with their yearly clinical visits. ^¶: patients will be asked to consider the burden of out-of-pocket expenses in the 12 months prior to visit.