PPI: protein–protein interaction (or genes encoding interacting proteins). Bold: same variant identified in cancer (somatic); underlined: same variant identified in lung cancer (somatic). Recurrently mutated gene pairs (encoding interacting proteins) are grouped under the same grey shade. Each shade represents a different group of genes encoding interacting proteins. ^#: gene causally implicated in any human cancer; ^¶: mouse model with lung abnormalities; ⁺: gene implicated in congenital human disorders with features shared with those commonly found in CPAM patients; ^§: gene mutated in >10% lung cancer samples; ^ƒ: gene implicated in lung development.