Genetic profile of the congenital pulmonary airway malformation (CPAM) patients included in this study

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PPI: protein–protein interaction (or genes encoding interacting proteins). Bold: same variant identified in cancer (somatic); underlined: same variant identified in lung cancer (somatic). Recurrently mutated gene pairs (encoding interacting proteins) are grouped under the same grey shade. Each shade represents a different group of genes encoding interacting proteins. #: gene causally implicated in any human cancer; : mouse model with lung abnormalities; +: gene implicated in congenital human disorders with features shared with those commonly found in CPAM patients; §: gene mutated in >10% lung cancer samples; ƒ: gene implicated in lung development.