TABLE 1

Characteristics of study subjects

	Study
	BT dataset	GSE43696	GSE63142	GSE89809	GSE64913
Use	Longitudinal gene expression change	Meta-analysis (discovery)	Meta-analysis (discovery)	Meta-analysis (discovery)	Meta-analysis (validation)
PubMed ID [ref.]		24518246 [19]	25338189 [20]	28933920 [21]	28045928 [22]
Data type	RNA sequencing	Microarray	Microarray	Microarray	Microarray
Severe asthmatic subjects n	12	38	56	11	28
Males in severe asthmatic subjects %	50.00	26.32	NP	45.45	57.14
Mean±sd age in severe asthmatic subjects years	55.17±13.07	44.40±10.06	NP	53.00±12.04	40.57±13.96
Median (interquartile range) FEV₁ % pred^#	59 (54–68)	56 (40–71)	56±20 (mean±sem)	63 (52–75)	64 (26–123) (mean (range))
Maintenance oral corticosteroids^# %	41.67	NP	NP	28.57	23.53
Healthy controls n	0	20	27	18	42

BT: bronchial thermoplasty; FEV₁: forced expiratory volume in 1 s; NP: not provided in the data. ^#: value extracted from the original paper, not the published RNA microarray data.