TABLE 2

Multivariable analysis of determinants of neutrophil elastase (NE) activity in bronchiectasis

Linear regression analysisLogistic regression analysis to predict sputum NE >20 µg·mL−1Logistic regression analysis to predict sputum NE >50 µg·mL−1
β-estimate (95% CI)p-valueOR (95% CI)p-valueOR (95% CI)p-value
Pseudomonas aeruginosa infection11.5 (−6.0–29.0)0.22.17 (0.88–5.33)0.090.98 (0.28–3.38)0.9
Sputum colour (4-point scale)10.4 (4.3–16.6)0.0012.13 (1.50–3.03)<0.00012.80 (1.70–4.62)<0.0001
MRC dyspnoea score6.4 (1.4–11.4)0.011.57 (1.18–2.09)0.0022.43 (1.56–3.78)<0.0001
Exacerbation history (per 1 event)3.4 (1.4–5.3)0.0011.07 (0.96–1.19)0.21.16 (1.02–1.32)0.03
Radiological extent (per additional lobe)1.5 (0.1–2.9)0.031.12 (1.05–1.21)0.0021.09 (0.98–1.20)0.1
Male1.1 (−8.5–10.6)0.80.82 (0.40–1.45)0.50.61 (0.27–1.40)0.2
Infection with other organisms0.4 (−10.6–11.4)0.91.23 (0.61–2.46)0.60.69 (0.22–2.16)0.5
Age (per year)0.1 (−0.3–0.5)0.71.01 (0.99–1.04)0.41.01 (0.98–1.05)0.5
FEV1 % pred−0.1 (−0.3–0.1)0.30.98 (0.97–1.00)0.050.99 (0.98–1.01)0.5

MRC: Medical Research Council; FEV1: forced expiratory volume in 1 s.