TABLE 2

Frequency that different outcome measures were reported in the 123 randomised controlled trials (RCTs) and 38 systematic reviews (SRs) included in this methodological review

OutcomesFrequency of reporting
RCTsSRs
Patient-important outcomes
 Mortality101 (82%)29 (76%)
 Treatment success or failure77 (63%)29 (76%)
 Adverse effects73 (59%)26 (68%)
 Health status, symptoms and quality of life73 (59%)17 (45%)
 Duration of exacerbations42 (34%)20 (53%)
 Re-exacerbation, re-hospitalisation33 (27%)16 (42%)
 Exercise capacity14 (11%)1 (3%)
 Anxiety and depression6 (5%)1 (3%)
Surrogate, physiological and laboratory outcomes
 Lung function58 (47%)18 (47%)
 Arterial blood gases and oxygen saturation40 (33%)5 (13%)
 Microbiological response16 (13%)7 (18%)
 Biomarkers32 (26%)2 (5%)
 Medication use18 (15%)3 (8%)