TABLE 1

Sensitivity, specificity, positive predicted value (PPV) and negative predicted value (NPV) of high probability for recent and/or remote latent tuberculosis infection (cut-offs ≥10% or ≥50%) to detect a positive response or a conversion in the tuberculin skin test (TST) and interferon-γ release assays

Cut-offTestSensitivitySpecificityPPVNPV
10%TST80%48%47%81%
QFT85%40%23%93%
ESAT-6100%36%19%100%
CFP-10100%35%17%100%
All88%39%25%94%
50%TST54%71%58%67%
QFT50%69%26%87%
ESAT-669%66%23%94%
CFP-1060%65%18%92%
All57%67%31%86%

Results for TST and interferon-γ release assays are presented separately and in combination, i.e. positive result and/or conversion in any test, as well as negative result in all tests. QFT: QuantiFERON TB Gold In-Tube; ESAT-6: 6-kDa early secretory antigenic target; CFP-10: 10-kDa culture filtrate protein.