Demographic and pulmonary function in the total population and the groups with obstruction with decreased central drive index (ODCDI) <5 and >5 h−1
| Total population | ODCDI <5 h−1 | ODCDI >5 h−1 | p-value | |
| Subjects | 30 | 27 | 3 | |
| Sex | 0.804 | |||
| Male | 18 | 16 | 2 | |
| Female | 12 | 11 | 1 | |
| Age years | 67.06±12.08 | 67.18±12.36 | 66.00±11.26 | 0.875 |
| BMI kg·m−2 | 26.19±4.52 | 26.51±4.70 | 23.69±0.81 | 0.319 |
| ALS onset | 0.051 | |||
| Spinal | 21 | 21 | 0 | |
| Bulbar | 9 | 6 | 3 | |
| Time from ALS onset months | 38.53±28.34 | 39.24±29.71 | 32.66±13.86 | 0.712 |
| Time from NIV onset months | 10.96±16.93 | 11.55±17.66 | 5.66±7.23 | 0.577 |
| ALSFRS-R | 22.13±8.69 | 21.55±8.45 | 27.33±10.96 | 0.282 |
| NBS | 19.56±12.93 | 20.44±12.91 | 11.66±12.42 | 0.272 |
| FVC L | 1.24±0.68 | 1.22±0.67 | 1.42±0.83 | 0.638 |
| FVC % pred | 41.49±21.60 | 40.58±20.59 | 49.66±33.85 | 0.500 |
| PImax cmH2O | −27.82±17.50 | −27.60±17.82 | −29.66±17.95 | 0.851 |
| PEmax cmH2O | 46.67±36.93 | 42.16±37.54 | 42.00±38.35 | 0.835 |
| SNIP cmH2O | −24.67±16.90 | −24.88±17.74 | −23.00±8.54 | 0.860 |
| MIC L | 1.54±0.79 | 1.53±0.80 | 1.61±0.92 | 0.871 |
| PCF L·s−1 | 2.68±1.40 | 2.65±1.39 | 2.97±1.75 | 0.719 |
| PCFMIC L·s−1 | 3.21±1.57 | 3.22±1.58 | 3.12±1.80 | 0.917 |
| PCFMI-E L·s−1 | 3.02±0.93 | 3.05±0.98 | 2.78±0.22 | 0.649 |
BMI: body mass index; ALS: amyotrophic lateral sclerosis; NIV: noninvasive ventilation; ALSFRS-R: Revised Amyotrophic Lateral Sclerosis Functional Rating Scale; NBS: Norris scale bulbar subscore; FVC: forced vital capacity; PImax: maximum inspiratory pressure; PEmax: maximum expiratory pressure; SNIP: sniff nasal inspiratory pressure; MIC: maximum insufflation capacity; PCF: peak cough flow; PCFMIC: manually assisted PCF; PCFMI-E: mechanically assisted PCF.