Correlation coefficients and significance values for Aα-Val541 together with the number of patients assessed with complete data for analysis from the combined PiZZ cohort

ClinicalPatients nCorrelation coefficient rsp-value
FEV1 % pred237−0.284<0.001#
KCO % pred233−0.1240.030#
Perc15 HU191−0.1980.003#
HU910 %1910.1150.057
HU950 %1910.1820.006#

FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; KCO: transfer coefficient of the lung for carbon monoxide; Perc15: density below which the lowest 15% of voxels occurs; HU910 and HU950: proportion of voxels with density below these Hounsfield unit thresholds. Lung densitometric analysis assessing emphysema is shown as Perc15, HU910 and HU950. #: p-values which remained statistically significant following Holm–Bonferroni correction for multiple comparisons.