TABLE 2

Baseline characteristics by age and sex

<65 years≥65 years
Women (n=72)Men (n=36)p-valueWomen (n=79)Men (n=84)p-value
Age years48 (35–61)48 (39–58)0.87073 (69–77)74 (70–78)0.409
WHO-FC I/II/III/IV2/13/45/12 (3%/18%/62%/17%)1/15/16/4 (3%/42%/44%/11%)0.0701/5/69/4 (1%/6%/87%/5%)0/13/65/6 (0%/16%/77%/7%)0.177
BMI kg·m−226 (23–30)27 (23–29)0.95827 (24–30)26 (24–28)0.072
6MWD m301 (197–470)435 (325–484)0.055210 (150–264)235 (162–358)0.117
SBP mmHg123 (109–138)129 (118–144)0.137135 (119–155)134 (123–153)0.977
DLCO % predicted58 (42–71)61 (43–79)0.40043 (28–50)39 (29–52)0.850
eGFR mL·min−1 per 1.73 m278 (60–98)81 (72–112)0.53944 (33–57)50 (39–66)0.011
NT-proBNP ng·L−11266 (390–2470)1440 (545–2489)0.7712178 (932–5070)1761 (814–5353)0.520
Comorbidities
 Hypertension16 (25%)15 (45%)0.09743 (59%)45 (62%)0.762
 Diabetes mellitus8 (13%)8 (24%)0.14024 (33%)29 (40%)0.394
 Atrial fibrillation3 (5%)3 (9%)0.39413 (19%)22 (30%)0.121
 Ischaemic stroke1 (1.5%)1 (3%)0.6305 (7%)9 (12%)0.434
 Ischaemic heart disease4 (6%)4 (12%)0.3759 (12%)25 (34%)0.002
Number of comorbidities
 0 comorbidities42 (66%)14 (43%)18 (25%)10 (14%)
 1 comorbidity14 (22%)9 (27%)0.05028 (38%)18 (25%)0.011
 ≥2 comorbidities8 (12%)10 (30%)27 (37%)45 (66%)
Haemodynamic values
 mRAP mmHg8 (4–11)7 (5–15)0.6948 (4–12)7 (5–10)0.683
 mPAP mmHg49 (44–59)52 (44–60)0.60047 (41–54)45 (40–51)0.143
 PAWP mmHg8 (6–11)9 (7–11)0.5629 (6–12)9 (6–12)0.727
 Cardiac index L·min−1·m−22.3 (1.9–2.8)2.3 (1.9–2.7)0.6312.1 (1.8–2.5)2.2 (1.8–2.6)0.497
 PVR Wood units10 (8–13)10 (6–14)0.48410 (8–13)8 (6–10)0.005
PAH-targeted therapy
 Single46 (64%)26 (72%)59 (75%)72 (86%)
 Dual18 (25%)7 (19%)0.54514 (18%)6 (7%)0.114
 Triple3 (4%)000
 No treatment5 (7%)3 (8%)6 (8%)6 (7%)
Supportive therapy
 Anticoagulants47 (65%)18 (50%)0.19945 (57%)57 (68%)0.151
 Diuretics43 (60%)17 (47%)0.32760 (76%)65 (77%)0.829
 Supplemental oxygen10 (14%)5 (14%)0.60037 (47%)36 (43%)0.610

Data are presented as median (interquartile range) or n (%) unless otherwise stated. WHO-FC: World Health Organization functional class; BMI: body mass index; 6MWD: 6-min walking distance; SBP: systolic blood pressure; DLCO: diffusing capacity of the lung for carbon monoxide; eGFR: estimated glomerular filtration rate; NT-proBNP: N-terminal pro-brain natriuretic peptide; mRAP: mean right atrial pressure; mPAP: mean pulmonary arterial pressure; PAWP: pulmonary arterial wedge pressure; PAH: pulmonary arterial hypertension.