Boys | GLI versus Zapletal | Girls | GLI versus Zapletal | Boys versus girls p-value^{#} | |

Subjects n | 215 | 227 | |||

Age | 8.4±3.2 | 8.3±3.3 | |||

Children aged <6 years | 31.6 | 32.2 | |||

Height cm | 131.2±19.7 | 129.5±19.8 | |||

BMI kg·m^{−2} | 17.2±3.1 | 17.0±2.8 | |||

BMI z-score^{¶} | 0.37±1.28 | 0.41±1.30 | |||

Mean z-scores | |||||

GLI | |||||

FVC | 0.19**±0.94 | <0.001 | 0.18**±0.97 | <0.001 | 0.87 |

FEV_{1} | 0.31***±0.98 | <0.001 | 0.30***±1.03 | <0.001 | 0.90 |

FEV_{1}/FVC | 0.11±0.84** | 0.001 | 0.09±0.89* | <0.001 | 0.91 |

Zapletal [3, 4] | |||||

FVC | 0.44***±1.61*** | 0.35***±1.37*** | 0.55 | ||

FEV_{1} | 0.67***±1.61*** | 0.56***±1.55*** | 0.50 | ||

FEV_{1}/FVC | 0.28**±1.32*** | 0.63***±1.62*** | 0.021 | ||

Distribution of z-scores | <LLN^{+} | >ULN^{§} | <LLN^{+} | >ULN^{§} | Boys versus girls p-value |

GLI | |||||

FVC | 1.0 | 6.2 | 2.0 | 7.4 | 0.71 |

FEV_{1} | 2.2 | 7.6 | 3.1 | 11.3 | 0.37 |

FEV_{1}/FVC | 1.1 | 2.7 | 4.6 | 4.6 | 0.067 |

Zapletal [3, 4] | |||||

FVC | 9.2 | 23.1 | 5.9 | 16.2 | 0.06 |

FEV_{1} | 6.1 | 29.3 | 6.8 | 22.2 | 0.27 |

FEV_{1}/FVC | 7.6 | 14.6 | 6.7 | 24.2 | 0.061 |

Data are presented as mean z-scores±sd or %, unless otherwise stated. BMI: body mass index; FVC: forced vital capacity, FEV_{1}: forced expiratory volume in 1 s. ^{#}: comparisons of z-score difference performed by Student's t-test. Comparison of proportions of subjects relative to the LLN and ULN were performed by Chi-squared test or Fisher's exact test except when observed frequencies were <5. Means were compared to 0 using paired Student's t-tests and sds were compared to 1 using Chi-squared tests for variance; ** ^{¶}**: Rolland-Cachera