Odds ratios for failure of fibrinolysis and subgroup surgical referral, determined using a univariate logistic regression model
| Covariate | Additional procedure | Surgical referral | ||
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Urokinase versus t-PA/DNAse | 0.66 (0.28–1.59) | 0.36 | 0.59 (0.17–2.13) | 0.43 |
| Age | 1 (0.97–1.02) | 0.95 | 0.99 (0.95–1.02) | 0.45 |
| Positive bacterial culture | 1.71 (0.71–4.16) | 0.23 | 2 (0.59–6.79) | 0.27 |
| Hospitalisation-to-drainage duration | 0.93 (0.85–1.01) | 0.07 | 0.87 (0.72–1.05) | 0.14 |
| Drainage-to-lysis duration | 1.13 (0.93–1.36) | 0.22 | 1.19 (0.96–1.47) | 0.12 |
| Non-image-guided versus image-guided procedure | 2.59 (0.89–7.56) | 0.08 | 0.88 (0.17–4.44) | 0.88 |
| Tube size (ref. 8–12 French) | ||||
| 14–18 French | 1.06 (0.4–2.78) | 0.91 | 1.54 (0.41–5.79) | 0.53 |
| 20–24 French | 4.86 (1.26–18.77) | 0.02 | 1.72 (0.29–10.18) | 0.55 |
| Duration of fibrinolysis | 1.18 (0.98–1.41) | 0.08 | 1.05 (0.83–1.33) | 0.66 |
| Duration of drainage (ref. 1–3 days) | ||||
| 4–10 days | 1.25 (0.31–5.1) | 0.76 | 0.57 (0.1–3.16) | 0.52 |
| >10 days | 6.75 (1.16–39.2) | 0.03 | 1.5 (0.2–11) | 0.69 |
| Baseline area occupied by effusion (ref. ≤1/3) | ||||
| 1/3 to 2/3 of the hemithorax | 2.94 (1.02–8.5) | 0.04 | 1.69 (0.4–7.1) | 0.47 |
| >2/3 of the hemithorax | 4.33 (1.1–17.1) | 0.04 | 1.61 (0.24–10.9) | 0.49 |
| One versus multiple collections | 4.81 (1.48–15.66) | 0.009 | 2.53 (0.49–11.82) | 0.31 |
| Isolated versus grouped collections | 1.27 (0.43–3.69) | 0.67 | 2.45 (0.47–12.78) | 0.29 |
t-PA: tissue plasminogen activator.