Summary of demographics and results across International Society for Heart and Lung Transplantation bronchiolitis obliterans syndrome (BOS) grades

OverallNo BOSBOS-0pBOS-1BOS-2–3p-value
Age years51.5±13.747.4±16.852.6±10.952.2±13.955.6±12.50.690§
Time since transplant years4.0 (0.9–5.9)1.0 (0.6–8.8)4.1 (2.4–4.8)3.6 (0.9–6.3)5.0 (3.9–6.1)0.735ƒ
FEV1 % predicted87 (68–95)95 (94–97)*,#,¶90±4.7*,#,¶74±5.6*,¶,+56±8.2*,#,+<0.0001ƒ
LCI8.8 (7.4–9.9)7.6±0.84*,#,¶8.3±1.0*,#,¶9.3±1.0*,¶,+12.5 (10.8–14.1)*,#,+<0.0001ƒ
Scond0.04 (0.02–0.07)0.02±0.017*,#,¶0.04±0.03*0.06±0.04+0.09±0.04+<0.0001§

Data are presented as mean±sd or median (interquartile range), unless otherwise stated. For post hoc comparisons, unpaired t-tests were used where both cohorts were normally distributed (data expressed as mean±sd) or Mann–Whitney test for all others. FEV1: forced expiratory volume in the first second; LCI: lung clearance index; Scond: ventilation heterogeneity of the conductive lung zone; Sacin: ventilation heterogeneity of the acinar lung zone. *: p<0.05 versus BOS-0p, post hoc pairwise comparison; #: p<0.05 versus BOS-1, post hoc pairwise comparison; : p<0.05 versus BOS-2–3, post hoc pairwise comparison; +: p<0.05 versus no BOS, post hoc pairwise comparison; §: ANOVA; ƒ: Kruskal–Wallis test.