TABLE 1

Summary of demographics and results across International Society for Heart and Lung Transplantation bronchiolitis obliterans syndrome (BOS) grades

	Overall	No BOS	BOS-0p	BOS-1	BOS-2–3	p-value
Subjects	51	15	16	11	9
Age years	51.5±13.7	47.4±16.8	52.6±10.9	52.2±13.9	55.6±12.5	0.690^§
Time since transplant years	4.0 (0.9–5.9)	1.0 (0.6–8.8)	4.1 (2.4–4.8)	3.6 (0.9–6.3)	5.0 (3.9–6.1)	0.735^ƒ
FEV₁ % predicted	87 (68–95)	95 (94–97)*^,#,¶	90±4.7*^,#,¶	74±5.6*^,¶,+	56±8.2*^,#,+	<0.0001^ƒ
LCI	8.8 (7.4–9.9)	7.6±0.84*^,#,¶	8.3±1.0*^,#,¶	9.3±1.0*^,¶,+	12.5 (10.8–14.1)*^,#,+	<0.0001^ƒ
S_cond	0.04 (0.02–0.07)	0.02±0.017*^,#,¶	0.04±0.03*^,¶	0.06±0.04⁺	0.09±0.04⁺	<0.0001^§
S_acin	0.24±0.13	0.19±0.08^¶	0.19±0.11^¶	0.23±0.06^¶	0.40±0.12*^,#,+	<0.0001^§

Data are presented as mean±sd or median (interquartile range), unless otherwise stated. For post hoc comparisons, unpaired t-tests were used where both cohorts were normally distributed (data expressed as mean±sd) or Mann–Whitney test for all others. FEV₁: forced expiratory volume in the first second; LCI: lung clearance index; S_cond: ventilation heterogeneity of the conductive lung zone; S_acin: ventilation heterogeneity of the acinar lung zone. *: p<0.05 versus BOS-0p, post hoc pairwise comparison; ^#: p<0.05 versus BOS-1, post hoc pairwise comparison; ^¶: p<0.05 versus BOS-2–3, post hoc pairwise comparison; ⁺: p<0.05 versus no BOS, post hoc pairwise comparison; ^§: ANOVA; ^ƒ: Kruskal–Wallis test.