TABLE 3

The association between psychological and cognitive outcomes and physical activity (PA) and exercise capacity variables using multiple mixed effect random models

Independent variables	MoCA^# total score		HADS-A score		HADS-D score		PHQ-9 total score
Independent variables	β (95% CI)	p-value	β (95% CI)	p-value	β (95% CI)	p-value	β (95% CI)	p-value
PA variables
Steps per day per increased 100 steps	−0.0028 (−0.0095–0.0038)	0.407	−0.0038 (−0.0115–0.0038)	0.328	−0.0092 (−0.0153– −0.0030)	0.003	−0.0107 (−0.0191– −0.0023)	0.012
Walking duration mins per increased 10 mins	−0.038 (−0.099–0.022)	0.216	−0.030 (−0.099–0.040)	0.402	−0.084 (−0.140– −0.028)	0.003	−0.083 (−0.159– −0.007)	0.033
Walking intensity per increased 1 point	5.55 (−1.98–13.08)	0.148	−10.94 (−19.54– −2.33)	0.013	−14.94 (−21.90– −7.97)	<0.001	−10.31 (−19.71– −0.90)	0.032
Exercise capacity
ESWT
Walk distance per increased 10 m	0.003 (−0.002–0.009)	0.218	0.001 (−0.005–0.007)	0.848	−0.007 (−0.012– −0.002)	0.005	−0.007 (−0.013– −0.000)	0.049
Walk duration mins per increased 1 min	0.03 (−0.01–0.08)	0.187	0.01 (−0.05–0.06)	0.794	−0.05 (−0.09– −0.01)	0.016	−0.05 (−0.11–0.01)	0.096
Number of shuttles per increased 5 points	0.016 (−0.011–0.042)	0.253	0.004 (−0.027–0.034)	0.816	−0.036 (−0.061– −0.011)	0.004	−0.034 (−0.068– −0.001)	0.046
Walk distance in 6MWT per increased	0.035 (0.011–0.058)	0.005	−0.007 (−0.034–0.021)	0.639	−0.038 (−0.060– −0.016)	<0.001	−0.049 (−0.078– −0.019)	0.001
10 m

Models adjusted for baseline age, sex, body mass index, smoking pack-years, % predicted forced expiratory volume in 1 s, treatment group and time variable week. MoCA: Montreal Cognitive Assessment; HADS: Hospital Anxiety and Depression Scale; A: anxiety; D: depression; PHQ: Patient-Health Questionnaire; ESWT: endurance shuttle walk test; 6MWT: 6-min walk test.^#: adjusted for correlation between repeated measures.