Factors associated with pulmonary function test abnormalities
| Factors evaluated | OR (95% CI) | p-value |
| DC inheritance: AD non-TINF2 versus AR/XLR/TINF2 | 0.04 (<0.001–1.57) | 0.08 |
| DC triad features: 2 or 3 versus 0–1 | 0.90 (0.12–6.55) | 0.92 |
| Smoker versus nonsmoker | 70.85 (1.84– >999.999) | 0.02 |
| Sex: male versus female | 0.25 (0.02–2.70) | 0.25 |
| Age in years at PFT | 1.11 (0.99–1.24) | 0.07 |
| Lymphocyte telomere Z-score | 0.63 (0.20–1.94) | 0.42 |
| BMF: severe versus none or moderate | 17.36 (1.82–165.30) | 0.01 |
The multivariable regression model used includes dyskeratosis congenita (DC) inheritance (autosomal recessive (AR)/X-linked recessive (XLR)/TINF2 versus autosomal dominant (AD) non-TINF2), DC triad (0–1 versus 2–3), smoking, sex, age at pulmonary function testing (PFT) (integer), lymphocyte telomere Z-score, and bone marrow failure (BMF) (severe versus none/moderate). Overall, 38 patients were included in the multivariable regression model; five patients were excluded (four with unknown gene status and one without telomere length Z-score data). Significant p-values are in bold.