TABLE 2

Therapeutic effect and comparison

UNWOral expectorantComparison of the difference between the two treatments
Pre-therapyAfter 3 months of treatmentt-valuep-valuePre-therapyAfter 3 months of treatmentt-valuep-valueUNWOral expectorantF-valuep-value
FVC L2.29±0.922.34±0.97−0.7560.4572.36±0.982.34±0.90−0.7560.4570.05±0.22−0.04±0.251.7390.193
FEV1 L1.63±0.661.70±0.641.4410.1621.64±0.671.62±0.63−1.2230.2330.07±0.29−0.04±0.153.2510.077
FEV1 % predicted58.58±20.9559.92±19.241.3600.18658.96±19.4058.73±20.21−0.6320.5331.34±5.95−0.62±4.962.0630.157
FEV1/FVC %71.45±12.1772.20±13.940.6500.52269.33±15.7670.21±11.660.3830.7050.74±7.000.97±12.901.7010.198
Inspiratory capacity L1.57±0.611.71±0.65−0.3520.0581.67±0.701.68±0.60−0.3520.7280.14±0.20−0.02±0.275.3990.024
PEF L·s−14.11±1.484.35±1.751.9910.7284.29±1.744.40±1.610.1810.8580.24±0.710.03±0.971.1650.285
Sputum volume mL·24 h−145.19±37.6238.41±66.36−0.8580.39943.52±45.4745.70±41.230.4200.678−6.78±41.042.19±27.010.7920.378
Sputum viscosity2.44±0.933.11±0.85−3.0290.0052.30±0.872.74±0.81−2.1990.0370.67±1.140.44±1.053.0210.086
Purulent score6.04±0.984.87±1.25−5.6910.0015.46±1.385.63±1.180.7740.446−1.17±1.070.17±1.1219.9890.001
LCQ score
 Physical4.40±1.165.04±1.103.1190.0044.43±1.144.60±1.100.6600.5150.65±1.080.17±1.342.7360.104
 Psychological3.48±1.234.59±1.255.6400.0013.86±1.103.85±1.19−0.0310.9751.11±1.03−0.01±1.2816.1460.001
 Social4.05±1.354.81±1.383.3100.0034.39±1.174.13±1.37−1.0500.3030.77±1.21−0.26±1.279.8550.003
 Total score11.94±3.4514.45±3.574.4280.00112.71±2.9812.60±3.49−0.1700.8662.51±2.94−0.11±3.3811.3860.001
6MWD503.63±105.67529.48±115.673.4680.002521.74±110.87497.44±141.21−1.6040.12125.85±38.73−24.30±78.739.6180.003
Sputum cell classification
 Neutrophils %96.22±3.6495.99±5.45−0.2380.81494.98±8.2897.02±2.191.3230.198−0.23±4.942.03±7.841.4580.233
 Macrophages %1.61±3.001.19±1.72−0.8650.3952.54±7.501.03±1.37−0.9930.330−0.42±2.46−1.52±7.780.4110.524
 Eosinophils %0.80±1.191.53±3.901.2300.2300.81±1.190.86±1.160.3370.7390.73±3.020.05±0.731.2060.277
 Lymphocytes %1.37±2.261.29±1.43−0.1800.8581.63±1.621.10±2.13−1.1770.250−0.08±2.39−0.53±2.290.4940.485
TNF-α ×103 pg·mL−1 (n=17)1.45±1.091.26±1.370.4260.6761.81±2.151.43±0.910.7510.463−0.19±1.81−0.39±2.110.2890.598
IL-8 ×103 pg·mL−1 (n=16)273.25±158.15278.21±440.75−0.0420.967444.02±515.37289.16±157.511.4260.1744.95±473.71−154.86±434.311.5320.236
IL-6 ×103 pg·mL−1 (n=12)0.87±0.900.60±0.701.0590.3120.57±0.880.47±0.550.3940.701−0.28±0.91−0.10±0.870.3060.592

Data are presented as mean±sd, unless otherwise stated. UNW: 0.9% normal saline inhaled by ultrasonic nebuliser with warming; FVC: forced vital capacity; FEV1: forced expiratory volume in 1s; PEF: peak expiratory flow; LCQ: Leicester cough questionnaire; 6MWD: 6-min walk distance; TNF: tumour necrosis factor; IL: interleukin.