TABLE 1

Demographic and clinical characteristics of the cohort

TotalPulmonary hypertension group#Non-pulmonary hypertension groupp-value
Subjects620375245
Age years70.01±15.1571.09±15.6770.96±14.540.779
Male302 (48.71)179 (47.73)123 (50.20)0.547
Height cm168.00±14.50167.10±14.20169.00±14.990.184
Weight kg83.00±30.7184.37±30.4678.47±29.990.002
BMI kg·m−229.31±9.4230.03±9.9728.20±8.46<0.001
Race/ethnicity
 Non-Hispanic White458 (73.87)284 (75.73)174 (71.02)0.010
 Non-Hispanic Black20 (3.23)14 (3.73)6 (2.45)
 Hispanic26 (4.19)20 (5.33)6 (2.45)
 Other6 (0.97)1 (0.27)5 (2.04)
 Unknown110 (17.74)56 (14.93)54 (22.04)
Smoking history
 Nonsmoker261 (42.10)150 (40.00)11 (45.31)0.159
 Current smoker15 (2.42)12 (3.20)3 (1.22)
 Ex-smoker344 (55.48)213 (56.80)131 (53.47)
Underlying disease
 COPD136 (21.94)93 (24.80)43 (17.55)0.033
 ILD235 (37.90)137 (36.53)98 (40.00)0.384
 Embolism42 (6.77)23 (6.13)19 (7.76)0.432
 Heart disease353 (56.94)229 (61.07)124 (50.61)0.010
Haemodynamics
 mPAP mmHg27±1333±1220±5<0.001
 CO (TD) L·min−14.69±1.934.60±2.064.80±1.800.065
 CO (Fick) L·min−14.60±1.754.59±1.814.65±1.630.458
 PVR (TD) WU3.02±2.694.09±3.282.11±1.11<0.001
 PVR (Fick) WU3.10±2.644.00±3.262.18±1.31<0.001
 RAP mmHg7±59±65±4<0.001
 PCWP mmHg12±614±710±5<0.001
Inspiratory HRCT median (IQR)
 MPAD mm32.75 (7.35)34.60 (7.10)30.00 (6.50)<0.001
 PA:Ao0.95 (0.22)1.01 (0.23)0.87 (0.16)<0.001
 RPAD mm25.95 (5.35)27.00 (4.90)24.30 (5.10)<0.001
 LPAD mm25.20 (4.80)26.15 (4.50)24.10 (4.70)<0.001
 PA angle deg84.45 (29.57)80.17 (28.83)90.67 (30.62)<0.001
Expiratory HRCT median (IQR)
 MPAD mm32.80 (7.20)34.65 (7.05)30.50 (6.00)<0.001
 PA:Ao0.94 (0.21)0.99 (0.22)0.86 (0.16)<0.001
 RPAD mm25.50 (5.35)26.60 (5.00)23.80 (4.70)<0.001
 LPAD mm25.60 (4.90)26.10 (4.90)24.20 (4.70)<0.001
 PA angle deg94.44 (23.02)92.99 (22.46)98.56 (25.96)0.001

Data are presented as n, mean±sd or n (%), unless otherwise stated. BMI: body mass index; COPD: chronic obstructive pulmonary disease; ILD: interstitial lung disease; PA: pulmonary artery; mPAP: mean PA pressure; CO: cardiac output; TD: thermodilution technique; PVR: pulmonary vascular resistance; WU: Wood Units; RAP: right atrial pressure; PCWP: pulmonary capillary wedge pressure; HRCT: high-resolution computed tomography; IQR: interquartile range; MPAD: main PA diameter; PA:Ao: PA to ascending aorta ratio; RPAD: right PA diameter; LPAD: left PA diameter. #: mPAP ≥25 mmHg on right heart catheterisation.