Relative and absolute contraindications to the use of mechanical insufflation–exsufflation
| Relative contraindications | Absolute contraindications |
| Application after meals | Bulbous emphysema |
| Rapid increase in respiratory rate | Pneumothorax |
| Haemodynamic instability | Recent barotrauma |
| Severe bronchospasm during the session | Non-controlled asthma exacerbation |
| Severe chest wall pain | Severe hypotension |
| Significant pulmonary bleeding |