Discrimination of inflammatory phenotypes using gene expression

AUCp-valueCut-off pointSensSpecPPVNPVKappa
Eosinophilic asthma versus non-eosinophilic asthma
 Manual plugs0.850.10.39568071670.22
 Whole sample1.000.010.9967100100770.72
Neutrophilic asthma versus non-neutrophilic asthma
 Manual plugs1.000.0080.9980100100930.68
 Whole sample0.840.20.6280100100930.68

All measures are relative to the classification from the manual cell differential count. AUC: area under the curve; Sens: sensitivity; Spec: specificity; PPV: positive predictive value; NPV: negative predictive value; Kappa: Cohen's kappa coefficient for agreement with the gold-standard classification based on the cell differential count.