TABLE 5

Correlation between immune-related pneumonitis (IP) extension and underlying lung conditions

Case numberTimingUpper leftMiddle leftLower leftUpper rightMiddle rightLower rightIP lesions in RT fieldPossible triggers and/or other findings
1Baseline0RTRT0RTRTPseudomonas aeruginosa pneumonia and synergistic lymphocyte activation by immunotherapy and RT
IP26–50%76–100%26–50%51–75%51–75%26–50%80%
2BaselineLobectomyM0RT (T)0TRecall effect RT upper right and cryoablation lower left
IPLobectomy76–100%76–100%26–50%051–75%90%
3Baseline000T00No specific trigger but close to T; no correlation with RT
IP0001–25%000%
4Baseline00000RT (M)Recall effect RT
IP26–50%1–25%1–25%26–50%26–50%51–75%60%
5Baseline000000Rhinovirus bronchiolitis 2 months before
IP26–50%26–50%26–50%26–50%26–50%26–50%NA
6Baseline00T000Marked in the T side; drug-induced pneumonia 6 months before
IP76–100%76–100%76–100%26–50%26–50%51–75%NA
7Baseline0T0000NAMarked in the T region
IP51–75%76–100%76–100%26–50%26–50%26–50%
8Baseline00MRT (T)RT0Marked in the M region; Pneumocystis jiroveci pneumonia 18 months before
IP01–25%26–50%26–50%0025%
9Baseline0000RT (T)RT100%Lymphocyte activation by RT
IP000026–50%1–25%
10Baseline0RT (T)00RT0Recall effect RT
IP76–100%76–100%1–25%26–50%26–50%1–25%80%
11Baseline000M00No specific trigger but close to M
IP01–25%1–25%51–75%26–50%26–50%NA
12Baseline000RT (M)00Synergistic lymphocyte activation by immunotherapy and RT
IP1–25%26–50%026–50%26–50%075%
13BaselineRT00RT (T)RT (T)0Recall effect RT
IP26–50%26–50%1–25%51–75%76–100%76–100%100%
14Baseline0000M0None
IP76–100%76–100%76–100%51–75%76–100%76–100%NA
15BaselineRTRTRTRT (T)LobectomyRT (T)Synergistic lymphocyte activation by immunotherapy and RT
IP26–50%26–50%51–75%51–75%NA76–100%80%

In patients who underwent radiation therapy, radiation therapy (RT) is used in the baseline row to identify the lung regions included in the radiation field. The tumour manifestation (primary tumour (T) or metastasis (M)) is added in parenthesis whenever the tumour manifestation was located in that irradiated region. NA: not available.