TABLE 1

Patient characteristics

Case numberAge yearsSexTime of diagnosisTumour histologyStageIntrathoracic tumour manifestations at diagnosisChemotherapyRTIntrathoracic tumour manifestations before RTTime of RTEvents other than RT in the 18 months before the onset of IPIntrathoracic tumour manifestations before ICI
188MMay 2014Metastatic squamous cell carcinoma of the head and neckIVBilateral lung metastasis, right hilar metastasisNAYesBilateral lung metastasis, right hilar metastasisDec 2014 to Feb 2016Pseudomonas aeruginosa pneumoniaBilateral lung metastasis, right hilar metastasis
270MJan 2013
  • 1) Mixed small cell carcinoma and squamous cell carcinoma of the lung

  • 2) Squamous cell carcinoma of the lung

IIBPrimary carcinoma (mass) LUL (1), synchronous primary carcinoma RUL (2), left-sided metastatic mediastinal and hilar lymph nodes, small left pleural effusionCisplatin/etoposideYesPrimary carcinoma (mass) LUL (1), synchronous primary carcinoma RUL (2), left-sided metastatic mediastinal and hilar lymph nodes, small left pleural effusionJan to July 2013Lung metastasis cryoablationLLL metastasis extending to the chest wall
369MMay 2016Squamous cell carcinoma of the lungIVPrimary carcinoma of the RUL, homolateral LN metastasis, thoracic spine metastasis T7–T11NoYesPrimary carcinoma of the RUL, homolateral LN metastasis, thoracic spine metastasis T7–T11June 2016 (spine)NoPrimary carcinoma of the RUL, homolateral LN metastasis, thoracic spine metastasis T7–T11
458MJan 2010MelanomaIBNoneNoYesLung metastasis RLL (after incomplete surgical resection)July 2015Community-acquired pneumoniaNew nodule RUL
568FJune 2015MelanomaIIIBNonhypermetabolic nodule LLL, chest wall metastasisNoNoNANoRhinovirus bronchiolitis, recurrence of chest wall and liver metastasisChest wall metastasis
680MJune 2016Squamous cell carcinoma of the lungIVPrimary carcinoma LLL, previous left upper lobectomy in 2014 for adenocarcinoma of the LULCarboplatin/vinorelbine (first carcinoma) then carboplatin/gemcitabineNoNANoDrug-induced thrombopeniaPrimary carcinoma LLL, previous left upper lobectomy
775MMarch 2016Lung adenocarcinomaIVPrimary carcinoma LULNoNoNANoNoPrimary carcinoma LUL
859FJuly 2015Squamous cell carcinoma of the lungIVPrimary carcinoma (mass) RULCisplatin/vinorelbine then carboplatin/vinorelbineYesSurgical resection of RULJan to Feb 2016Pneumocystis jiroveci pneumoniaLocal recurrence LLL metastasis
951FJan 2014Small cell lung cancerIBPrimary carcinoma (mass) RLLCisplatin/etoposideYesPrimary carcinoma (mass) RLLFeb 2015 to March 2016NoPrimary carcinoma (mass) RLL
1057FFeb 2015Lung adenocarcinomaIVPrimary carcinoma (mass) LULPemetrexed then carboplatin/pemetrexedYesPrimary carcinoma (mass) LULSept to Oct 2015NoPrimary carcinoma (mass) LUL
1148MMarch 2007Right arm melanomaIBNoNoNoNANoNoMelanoma metastasis (mass) RUL
1271MFeb 2017Oesophageal adenocarcinomaIVOesophageal carcinoma, locoregional metastatic lymph nodesNoYesChest wall metastasisMarch 2017NoChest wall metastasis
1388MOct 2015Squamous cell carcinoma of the lungIIIAPrimary carcinoma of RUL extending to chest wall, mediastinal and right hilar lymph node metastasisGemcitabineYesPrimary carcinoma of RUL extending to chest wall, mediastinal and right hilar lymph node metastasisNov 2015 to Feb 2016NoPrimary carcinoma of RUL extending to chest wall, mediastinal and right hilar lymph node metastasis
1462MFeb 2007MelanomaIVMediastinal and hilar metastasis and metastasis of the RLLDacarbazineNoNANoNoMediastinal and hilar metastasis and metastasis of the RLL
1572MOct 2012Lung adenocarcinomaIIbPrimary carcinoma (mass) RUL and ML, satellite nodules RLLCisplatin/vinorelbine, then carboplatin/pemetrexedYesRUL+ML lobectomy bilateral metastatic adenocarcinomaOct 2017NoRUL+ML lobectomy bilateral metastatic adenocarcinoma

RT: radiotherapy; IP: immune-related pneumonitis; ICI: immune checkpoint inhibitors; LUL: left upper lobe; RUL: right upper lobe; LN: lymph node; LLL: left lower lobe; RLL: right lower lobe; ML: middle lobe; NA: not available.