Lung function and markers of inflammation in patients according to their 12-year adherence
| 12-year adherence | |||
| Good adherence# | Poor adherence¶ | p-value | |
| Lung function at follow-up | |||
| Pre-BD FEV1 % pred | 87 (75–99) | 86 (75–94) | 0.398 |
| Pre-BD FVC % pred | 97 (87–108) | 96 (87–106) | 0.374 |
| Pre-BD FEV1/FVC | 0.73 (0.67–0.78) | 0.74 (0.65–0.79) | 0.730 |
| Post-BD FEV1 % pred | 90 (79–99) | 89 (81–96) | 0.682 |
| Post-BD FVC % pred | 99 (85–108) | 97 (88–105) | 0.416 |
| Post-BD FEV1/FVC | 0.74 (0.68–0.79) | 0.76 (0.68–0.81) | 0.320 |
| FEV1 reversibility mL | 65 (7.5–123) | 100 (40–170) | 0.010 |
| FEV1 reversibility % initial FEV1 | 2.7 (0.29–5.0) | 3.8 (1.6–6.8) | 0.039 |
| Lung function change | |||
| ΔFEV1 % pred·year–1 | −0.39 (−0.88–0.40) | −0.54 (−1.2–0.0) | 0.026 |
| ΔFEV1 mL·year–1 | −40 (−56– −22) | −46 (−81– −26) | 0.050 |
| ΔFVC % pred·year–1 | 0.11 (−0.47–0.82) | −0.21 (−0.87–0.45) | 0.034 |
| ΔFVC mL·year–1 | −32 (−56– −10) | −36 (−64– −13) | 0.329 |
| ΔFEV1/FVC year–1 | −0.005 (−0.008– −0.0001) | −0.005 (−0.008– −0.002) | 0.316 |
| Markers of inflammation | |||
| Blood eosinophils ×109 L−1 | 0.17 (0.09–0.28) | 0.18 (0.10–0.27) | 0.549 |
| Total IgE kU·L−1 | 71 (24–165) | 56 (26–178) | 0.956 |
| FENO (ppb) | 10 (5–19) | 11 (5–18) | 0.683 |
| Blood neutrophils ×109 L−1 | 4.2 (3.5–5.3) | 3.5 (2.7–4.6) | 0.001 |
| IL-6 pg·mL−1 | 1.9 (1.2–3.2) | 1.8 (1.1–3.3) | 0.537 |
| hsCRP mg·L−1 | 1.0 (0.48–2.3) | 1.4 (0.62–2.9) | 0.224 |
Data are presented as median (interquartile range) unless otherwise stated. Statistical significance was evaluated by independent-samples Mann–Whitney U-test. BD: bronchodilator; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FENO: exhaled nitric oxide fraction; IL: interleukin; hsCRP: high-sensitivity C-reactive protein. #: ≥80% adherence, n=82; ¶: <80% adherence, n=99.