TABLE 1

Associations between characteristics at enrolment and z-scored cytomegalovirus serology values in 806 Tucson Epidemiological Study of Airway Obstructive Disease participants based on univariate regression models

Participantsβ-coefficient (95%CI)p-value#
Age in years8060.025 (0.02–0.03)<0.001
Sex (ref.: male)<0.001
 Female485/8060.27 (0.13–0.41)
Education level (ref.: >12 years)<0.001
 ≤12 years496/8060.33 (0.19–0.47)
BMI category (ref.: normal weight)
 Underweight15/7840.21 (−0.31–0.72)0.427
 Overweight285/7840.02 (−0.13–0.17)0.768
 Obese65/7840.33 (0.06–0.59)0.014
Smoking status (ref.: never)
 Former222/805−0.12 (−0.29–0.06)0.189
 Current281/805−0.01 (−0.17–0.16)0.943
Airflow limitation (ref.: stage 0)
 Stage 143/8060.13 (−0.18–0.44)0.400
 Stage 256/8060.21 (−0.06–0.48)0.130
 Stage 3+417/8060.57 (0.08–1.05)0.021
Doctor-diagnosed asthma (ref.: no)
 Yes97/8060.13 (−0.09–0.34)0.242
FEV1 % predicted806−0.005 (−0.008– −0.001)0.011
FVC % predicted806−0.003 (−0.007–0.001)0.116
FEV1/FVC ratio806−0.012 (−0.019– −0.005)0.001
FEF25–75% % predicted806−0.002(−0.004−0.0003)0.022
Smoking history pack-years
 All8050.003 (0.0002–0.006)0.032
 Only smokers5030.007 (0.003–0.10)0.001
Chlamydophila pneumoniae serology in z-scores8060.17 (0.10–0.24)<0.001
Mycoplasma pneumoniae serology in z-scores8060.31 (0.24–0.38)<0.001
C-reactive protein in z-scores8060.14 (0.07–0.21)<0.001

Numbers vary depending on missing information for some variables. Body mass index (BMI) was categorised as: underweight, <18.5 kg·m−2; normal weight, 18.5–24.9 kg·m−2; overweight, 25–29.9 kg·m−2; obese, BMI ≥30 kg·m−2. Level of education was categorised as ≤12 years or >12 years of formal education. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory flow at 25–75% FVC. #: based on simple linear regression predicting cytomegalovirus serology z-scores. : stage 0, FEV1/FVC ratio ≥70%; stage 1, FEV1/FVC ratio <70% and FEV1 ≥80% predicted; stage 2, FEV1/FVC ratio <70% and FEV1 50–80% predicted; stage 3+4, FEV1/FVC ratio <70% and FEV1 <50% predicted.