TABLE 3

Impact of winter season on different clinical parameters and outcomes in comparison to summer season

All PE patients (sex-unspecific analyses)Univariate analysis OR (95% CI)p-valueMultivariate analysis# OR (95% CI)p-value
Reperfusion treatment
 Surgical pulmonary embolectomy0.94 (0.81–1.09)0.4151.00 (0.86–1.16)0.950
 Systemic thrombolysis1.03 (1.00–1.06)0.0411.04 (1.01–1.07)0.008
Risk stratification
 Haemodynamically unstable PE1.01 (0.98–1.02)0.9421.01 (0.99–1.03)0.238
 Right ventricular dysfunction1.04 (1.03–1.06)<0.0011.04 (1.03–1.06)<0.001
 Tachycardia0.94 (0.90–0.98)0.0050.96 (0.91–1.00)0.041
 Syncope1.01 (0.97–1.05)0.5821.00 (0.96–1.04)0.955
In-hospital outcomes
 CPR1.02 (1.00–1.05)0.0681.03 (1.01–1.05)0.017
 In-hospital death1.02 (1.01–1.04)0.0081.04 (1.02–1.05)<0.001
Intra-hospital bleeding events
 Gastro-intestinal bleeding0.98 (0.93–1.03)0.4000.97 (0.95–1.05)0.869
 Subarachnoid bleeding0.80 (0.69–0.93)0.0040.80 (0.69–0.93)0.005
 Intracerebral bleeding0.93 (0.86–1.01)0.0820.93 (0.86–1.01)0.073
MenUnivariate OR (95% CI)p-valueMultivariate OR (95% CI)p-value
Reperfusion treatment
 Surgical pulmonary embolectomy0.94 (0.77–1.15)0.5241.00 (0.82–1.22)0.973
 Systemic thrombolysis1.06 (1.01–1.10)0.0111.07 (1.03–1.12)0.002
Risk stratification
 Haemodynamically unstable PE0.99 (0.96–1.02)0.4241.00 (0.97–1.03)0.936
 Right ventricular dysfunction1.05 (1.03–1.07)<0.0011.05 (1.03–1.07)<0.001
 Tachycardia0.93 (0.88–1.00)0.0360.95 (0.89–1.02)0.145
 Syncope1.00 (0.95–1.07)0.9010.99 (0.94–1.05)0.821
In-hospital outcomes
 CPR1.00 (0.97–1.04)0.8031.01 (0.98–1.05)0.483
 In-hospital death1.02 (0.99–1.04)0.1541.03 (1.01–1.06)0.015
Intra-hospital bleeding events
 Gastro-intestinal bleeding0.95 (0.88–1.02)0.1850.97 (0.90–1.04)0.406
 Subarachnoid bleeding0.94 (0.75–1.17)0.5650.94 (0.75–1.19)0.619
 Intracerebral bleeding1.02 (0.91–1.13)0.7851.01 (0.91–1.13)0.829
WomenUnivariate OR (95% CI)p-valueMultivariate OR (95% CI)p-value
Reperfusion treatment
 Surgical pulmonary embolectomy0.95 (0.76–1.19)0.6471.00 (0.80–1.24)0.978
 Systemic thrombolysis1.01 (0.97–1.05)0.6661.01 (0.97–1.06)0.522
Risk stratification
 Haemodynamically unstable PE1.01 (0.99–1.04)0.3321.02 (0.99–1.05)0.117
 Right ventricular dysfunction1.04 (1.02–1.05)<0.0011.03 (1.02–1.05)<0.001
 Tachycardia0.95 (0.89–1.00)0.0680.96 (0.90–1.02)0.153
 Syncope1.01 (0.96–1.07)0.5921.01 (0.96–1.06)0.812
In-hospital outcomes
 CPR1.04 (1.01–1.08)0.0161.05 (1.01–1.08)0.008
 In-hospital death1.03 (1.00–1.05)0.0251.04 (1.02–1.06)0.001
Intra-hospital bleeding events
 Gastro-intestinal bleeding1.00 (0.94–1.08)0.9181.02 (0.95–1.09)0.566
 Subarachnoid bleeding0.70 (0.57–0.86)0.0010.70 (0.57–0.86)0.001
 Intracerebral bleeding0.85 (0.76–0.96)0.0060.85 (0.76–0.95)0.004

PE: pulmonary embolism; CPR: cardiopulmonary resuscitation. #: Adjustment I; : Adjustment II.