Outcome and complication differences in the studied populations based on D-dimer levels
| First author [ref.] | Patients n | Compared data | Higher value | p-value |
| Chen [14] | 274 | D-dimer: deceased/survivors | Deceased: 4.6 µg·mL−1 | |
| Guan [3] | 1099 | D-dimer: CEP/non-CEP | ≥0.5 mg·L−1 in 69.4% of CEP | |
| D-dimer: severe/non-severe | ≥0.5 mg·L−1 in 59.6% of severe | |||
| Han [15] | 94 | D-dimer: COVID-19/non-COVID-19 | COVID-19: 10.36±25.31 mg·L−1 | <0.001 |
| D-dimer: severe/non-severe COVID-19 | Severe COVID-19: 19.1±35.48 mg·L−1 | <0.05 | ||
| Huang [1] | 41 | D-dimer: ICU/non-ICU | ICU: 2.4 mg·L−1, range 0.6–14.4 mg·L−1 | 0.0042 |
| Tang [16] | 449 | D-dimer: heparin yes/no | No heparin: >3.0 µg·mL. | |
| Mortality#: heparin yes/no | No heparin#: 52.4% | 0.017 | ||
| Tang [17] | 183 | D-dimer: deceased/survivors | Deceased: 2.12 µg·mL−1, range 0.77–5.27 µg·mL−1 | <0.001 |
| Wan [26] | 135 | D-dimer: severe/non-severe | Severe: 0.6 mg·L−1, range 0.4–1.1 mg·L−1 | <0.001 |
| Wang [18] | 138 | D-dimer: ICU/non-ICU | ICU: 414 mg·L−1, range 191–1324 mg·L−1 | <0.001 |
| 33 | D-dimer: deceased/survivors | Deceased: >1000 mg·L−1 | <0.05 | |
| Wang [19] | 339 | D-dimer: deceased/survivors | Deceased: 4.38 mg·L−1, range 1.32–17.0 mg·L−1 | <0.001 |
| Wu [6] | 201 | D-dimer: ARDS/non-ARDS | ARDS: 0.52 µg·mL−1 higher than non-ARDS | <0.001 |
| D-dimer: ARDS deceased/survivors | ARDS deceased: 2.10 µg·mL−1 higher than survivors | <0.001 | ||
| Li [25] | 25 | D-dimer deceased: first test/last test | Last test: 9.93 mg·L−1, IQR 2.65–54.8 mg·L−1 | |
| Yin [20] | 553 | Mortality#: COVID-19 heparin yes/no | No heparin#: 52.4% | 0.017 |
| Mortality: non-COVID-19 heparin yes/no | ||||
| Zhang [21] | 95 | D-dimer: severe/non-severe | >1 mg·L−1: 81.2% severe | <0.001 |
| D-dimer: CEP/non-CEP | >1 mg·L−1: 71.9% CEP | <0.001 | ||
| Zhang [24] | 140 | D-dimer: severe/non-severe | Severe: 0.4 µg·mL−1, range 0.2–2.4 µg·mL−1 | <0.001 |
| Zhou [22] | 172 | D-dimer: deceased/survivors | Deceased: 5.2 µg·mL−1, range 1.5–21.16 µg·mL−1 | <0.001 |
| D-dimer¶: deceased/survivors | >1 µg·mL−1 in 81% of deceased | <0.001 | ||
| Zhang [23] | 7 | D-dimer: pre-limb ischaemia/limb ischaemia | >21 µg·mL−1 in 71.4% of patients with limb ischaemia |
CEP: composite end-point; ICU: intensive care unit; ARDS: acute respiratory distress syndrome; IQR: interquartile range. #: D-dimer >3.0 µg·mL−1; ¶: D-dimer >1.0 µg·mL−1.