CT findings, diagnostic procedures, therapy, complications, and survival of 16 patients with amyloidosis of the respiratory system
No. | CT findings (maximum diameter) | Diagnostic procedure | Therapy | Complications during follow-up | Survival |
1 | Single nodule (12 mm) | VATS-LB | None | Multiple nodules, multiple cysts (17 years later) | Alive: 17 years |
2 | Single nodule (30 mm) | VATS-LB | None, surgery: MALT lymphoma | MALT lymphoma (10 years later) | Alive: 16 years |
3 | Multiple nodules+multiple micronodules >10 (30 mm), calcification, multiple cysts | VATS-LB | None, surgery: MALT Lymphoma | MALT lymphoma (5 and 10 years later), Sjögren's syndrome (4 years later) | Alive: 20 years |
4 | Multiple (4) nodules (20 mm)+multiple cysts, calcification | VATS-LB | Surgery: MALT lymphoma | None | Alive: 10 years |
5 | Multiple (2) nodules (18 mm)+multiple cysts | VATS-LB | None | Cysts increase (9 years later) | Alive: 11 years |
6 | Multiple (3) nodules (15 mm)+multiple micronodules+multiple cysts, calcification | VATS-LB | RA therapy | None | Died at 7 years of pneumonia |
7 | Multiple (>10) nodules (10 mm)+multiple micronodules | VATS-LB | None | None | Died at 5 years of pancreatic cancer |
8 | Tracheobronchial thickening+CHP | TBB, CHP via VATS | None | None | Alive: 3 years |
9 | Mediastinal and hilar lymphadenopathy, calcification | EBUS-TBNA | None | None | Alive: 6 years |
10 | Bilateral pleural effusion+pleural thickening | VATS pleural biopsy | Dexamethasone | None | Died at 1 year of MM |
11 | Bilateral pleural effusion+mediastinal lymphadenopathy+interlobular septal thickening | VATS-LB and VATS-MLNB | Prednisolone | None | Died at 1.8 years of cardiac and respiratory amyloidosis |
12 | DAH | TBLB | Melphalan+prednisolone | None | Died at 1 year of MM |
13 | PCP | TBLB | RA therapy | None | Died at 3 years of cardiac and renal failure |
14 | DAH | TBLB | None | Diffuse pulmonary haemorrhage (3 times) | Died at 3 years of cardiac failure |
15 | Lung cancer (single nodule) | VATS lobectomy | None | None | Alive: 0.6 year |
16 | Bilateral pleural effusion+mediastinal lymphadenopathy | EBUS-TBNA | Melphalan+dexamethasone | None | Died at 4 months of cardiac and renal failure |
CT: computed tomography; VATS-LB: video-assisted thoracoscopic lung biopsy; MALT: mucosa-associated lymphoid tissue; RA: rheumatoid arthritis; CHP: chronic hypersensitivity pneumonitis; TBB: transbronchial biopsy; EBUS-TBNA: endobronchial ultrasound-guided transbronchial needle aspiration; DAH: diffuse alveolar haemorrhage; MM: multiple myeloma; PCP: pneumocystis pneumonia; VATS-MLNB: VATS mediastinal lymph node biopsy; TBLB: transbronchial lung biopsy.