TABLE 1

Patient characteristics and virology results

Patient IDSexAge yearsTobacco exposure#Environmental exposureConditionHRCT patternHistologyIPF treatmentHSV-1HSV-2VZVhCMV viral load
(log10 copies per 106 cells)
EBV viral load
(log10 copies per 106 cells)
HHV-6 viral load
(log10 copies per 106 cells)
HHV-7HHV-8HVSTTV viral load
(log10 copies per 106 cells)
Viral DNA detected
#01Male5510IPFUIPUIPNone3.1NDEBV
#02Male4400IPFUIPUIPPirfenidone3.3EBV
#03Male4910IPFPossible UIPProbable UIPNone2.42.43.1EBV, HHV-6, TTV
#04Male6210IPFUIPUIPPirfenidone and prednisone (exacerbation)2.6HHV-6
#05Male6611IPFUIPUIPPrednisone2.12.1HHV-6, TTV
#06Male6810IPFProbable UIPUIP + ExacerbationPirfenidone2.5TTV
#07Male5800IPFUIPUIPNone2.42.9EBV, TTV
#08Male7411IPFPossible UIPUIPNintedanib3.3EBV
#09Male5010IPFPossible UIPUIPNone2.02.23.4EBV, HHV-6, TTV
#10Male6110IPFPossible UIPUIPNintedanib3.12.4EBV, HHV-6
#11Male5711IPFPossible UIPUIPPirfenidone3.9+EBV, HHV-7
#12Male5110IPFUIPUIP + ExacerbationNone1.62.02.7hCMV, HHV-6, TTV
#13Male6011IPFUIPUIPPirfenidone2.71.91.8EBV, HHV-6, TTV
#14Male6100IPFPossible UIPUIPPirfenidone1.72.7HHV-6, TTV
#15Male6411IPFUIPUIP + ExacerbationPirfenidone3.81.7EBV, TTV
#16Female4601IPFPossible UIPUIPPirfenidone2.2HHV-6
#17Male5711IPFUIPUIP + ExacerbationNintedanib5.81.67.5hCMV, HHV-6, TTV
#18Male5810IPFUIPUIPPirfenidone2.92.3+2.2EBV, HHV-6, HHV-7, TTV
#19Female5010IPFUIPUIP + ExacerbationPirfenidone0.31.8+3.8EBV, HHV-6, HHV-7, TTV
#21Male6900AdenocarcinomaNANANA3.22.3HHV-6, TTV
#22Female7110AdenocarcinomaNANANA2.93.8EBV, TTV
#23Female7710AdenocarcinomaNANANA3.0TTV
#24Female7300Epidermoid carcinomaNANANA4.0+1.9EBV, HHV-7, TTV
#25Male5210AdenocarcinomaNANANA1.83.0hCMV, TTV
#26Male7120AdenocarcinomaNANANA2.72.2HHV-6, TTV
#27Female6820Epidermoid carcinomaNANANA3.02.2EBV, TTV
#28Male6010COPD/
emphysema
NANANA2.62.82.4EBV, HHV-6, TTV
#29Male5211COPD/
emphysema
NANANA2.92.5HHV-6, TTV

Abbreviations: HRCT: high-resolution computed tomography; IPF: idiopathic pulmonary fibrosis; HSV: herpes simplex virus; VZV: varicella-zoster virus; hCMV: human cytomegalovirus; EBV: Epstein–Barr virus; HHV: human herpesvirus; HVS: herpesvirus saimiri; TTV: torque teno virus; UIP: usual interstitial pneumonia; NA: not applicable; ND: not done. #: current=2, former=1, never=0; : yes=1, no=0.