Lung function data
| Lean | Obese | p-value# | |||
| Control | Asthma | Control | Asthma | ||
| FEV1 % pred | 99.1±9.2* | 89.2±16.6 | 99.0±12.3 | 83.0±13.6 | 0.02 |
| FVC % pred | 104.3±5.4* | 98.5±14.7* | 96.9±11.9* | 80.9±9.8 | <0.001 |
| FEV1/FVC % | 77.0±5.7 | 76.7±8.5 | 82.0±6.9 | 83.1±4.2 | 0.051 |
| ERV % pred | 62.5±39.8 | 69.1±29.7 | 44.3±35.4 | 51.4±46.5 | 0.53 |
| TLC % pred | 103.4±8.72* | 98.2±14.0 | 96.1±12.8 | 87.4±8.9 | 0.02 |
| RV % pred | 132.4±39.4* | 129.1±36.5* | 99.5±30.4 | 82.7±36.9 | <0.01 |
| RV/TLC % pred | 128.3±30.2 | 136.3±42.5* | 102.5±26.8 | 93.9±35.5 | 0.02 |
| FRC % pred | 96.0±22.8+ | 98.6±10.0+ | 76.2±11.9 | 73.9±16.6 | <0.001 |
| sGaw % pred | 119±92.0 | 127.9±72.6 | 107.8±78.1 | 156.6±92.9 | 0.59 |
| PC20 mg·mL−1 methacholine | 50 (22.2–64)¶ | 2.8 (0.1–12.8) | 64 (64–64)¶ | 1.4(0.03,16) | <0.0001 |
Data are presented as mean±sd or median (range), unless otherwise stated. Predicted values for spirometry are based on NHANES III [21], and those for lung volumes are based on Goldman and Becklake [22]. FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; ERV: expiratory reserve volume; TLC: total lung capacity; RV: residual volume; FRC: functional residual capacity; sGaw: specific airway conductance; PC20: provocative concentration causing a 20% fall in FEV1. #: p-value shown for one-way analysis of variance for normally distributed variables, and Kruskal–Wallis test for non-parametric variables; *: p<0.05 compared with Obese Asthma group, post hoc comparison with Bonferroni correction; ¶: p<0.05 compared with asthma groups, post hoc comparison with Bonferroni correction; +: p<0.05 compared with obese groups, post hoc comparison with Bonferroni correction.