TABLE 1

Demographic and baseline clinical features of adolescent tuberculosis cases, Ukraine, 2015–2018 (n=2491)

Ages 10–14 yearsAges 15–19 yearsAges 10–19 years
Subjects n (row %)557 (22.4)1934 (77.6)2491 (100)
Sex
 Female280 (50.3)901 (46.6)1181 (47.4)
 Male277 (49.7)1033 (53.4)1310 (52.6)
HIV status
 Infected, no ART start date documented1 (0.2)9 (0.5)10 (0.4)
 Infected, not on ART at start of TB treatment29 (5.2)23 (1.2)52 (2.1)
 Infected, on ART at start of TB treatment13 (2.3)13 (0.7)26 (1.0)
 Uninfected479 (86.0)1818 (94.0)2297 (92.2)
 Unknown35 (6.3)71 (3.6)106 (4.3)
Urban or rural residence
 Urban292 (52.4)1137 (58.8)1429 (57.4)
 Rural262 (47.1)784 (40.5)1046 (42.0)
 Unknown3 (0.5)13 (0.7)16 (0.6)
Migration status
 Migrant6 (1.1)26 (1.3)32 (1.3)
 Nonmigrant551 (98.9)1908 (98.7)2469 (98.7)
Oblast
 Conflict-affected28 (5.0)99 (5.1)127 (5.1)
 Not conflict-affected529 (95.0)1835 (94.9)2364 (94.9)
History of alcohol use
 Yes0 (0.0)17 (0.9)17 (0.7)
 No557 (100.0)1917 (99.1)2474 (99.3)
History of incarceration
 Yes0 (0.0)24 (1.2)24 (1.0)
 No557 (100.0)1910 (98.8)2467 (99.0)
Probable source case identified
 Yes110 (19.7)214 (11.1)324 (13.0)
 No447 (80.3)1720 (88.9)2167 (87.0)
Case classification
 New537 (96.4)1863 (96.3)2400 (96.3)
 Recurrent20 (3.6)71 (3.7)91 (3.7)
Diagnosis
 Microbiological446 (80.1)1756 (90.8)2202 (88.4)
 Clinical111 (19.9)178 (9.2)289 (11.6)
Site of disease
 Exclusively intrathoracic455 (81.7)1824 (94.3)2279 (91.5)
 Exclusively extrathoracic85 (15.3)66 (3.4)151 (6.1)
 Intra- and extrathoracic17 (3.1)44 (2.3)61 (2.4)
Lung cavitation
 Cavitary pulmonary TB56 (10.1)638 (33.0)694 (27.9)
 Noncavitary pulmonary TB264 (47.4)1076 (55.6)1340 (53.8)
 No pulmonary TB237 (42.5)220 (11.4)457 (18.3)
Pleural TB
 Isolated pleural30 (5.4)131 (6.8)161 (6.5)
 Pleural+pulmonary12 (2.2)45 (2.3)57 (2.3)
 No pleural involvement515 (92.4)1758 (90.9)2273 (91.2)
Baseline drug resistance profile
 INH- and RIF-susceptible379 (68.0)1289 (66.6)1668 (67.0)
 INH-monoresistant11 (2.0)108 (5.6)119 (4.8)
 RR but not pre-XDR20 (3.6)153 (0.8)173 (6.8)
 RR, no SLD DST11 (2.0)63 (3.3)74 (3.0)
 Pre-XDR but not XDR12 (2.1)73 (10.8)85 (3.4)
 XDR6 (1.1)38 (2.0)44 (1.8)
 No result#118 (21.2)210 (10.9)328 (13.2)

Data are presented as n (column %), unless otherwise stated. ART: antiretroviral therapy; TB: tuberculosis; INH: isoniazid; RIF: rifampicin; RR: rifampicin-resistant; SLD: second-line drug; DST: drug susceptibility testing; XDR: extensively drug-resistant. #: DST result was not documented in 39 (1.8%) of 2202 microbiologically confirmed cases.