TABLE 1

Outcome measures used in the study and their assessment time frame

Outcomes - assessment toolsTime frame of assessments
Baseline (pre-ICU admission)At randomisation24 h after extubationAt ICU dischargeAt hospital discharge
MIP
MEP
Fatigue Resistance Index
Duration of mechanical ventilation
Duration of ICU length of stay
MRC scale for muscle strength
Functional independence measurement
SF-36
EuroQol 5D-5L

ICU: intensive care unit; MIP: maximal inspiratory pressure; MEP: maximal expiratory pressure; MRC: Medical Research Council; SF-36: 36-item short form survey.