Baseline characteristics and pre-evaluation data at time of lung transplantation listing for patients without acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) before lung transplantation and patients with AE-IPF before lung transplantation

No AE-IPF groupAE-IPF groupp-value
Baseline characteristics
 BMI kg·m−228±428±40.28
Comorbidities and smoking history
 Diabetes mellitus11 (21)12 (32)0.33
 Hypertension18 (35)21 (57)0.051
 Coronary artery disease25 (48)22 (59)0.39
 Congestive heart failure (systolic)01 (3)0.42
 Smoking history38 (73)25 (68)0.65
 Ever-smoker pack-years23±1116±290.42
Pulmonary function tests
 FEV1 % pred52±1550±150.42
 FVC % pred47±1343±120.2
 TLC % pred48±946±90.41
 RV % pred44±1533±100.004
DLCO % pred28±1124±100.17
 Baseline oxygen saturation %90±688±60.09
 6-min walk distance m254±99218±740.08
 Lowest oxygen saturation %83±1381±60.61
Blood tests
 Creatinine mg·dL−10.91±0.20.82±0.30.096
 Albumin g·dL−13.4±0.532.95±0.540.0002
 WBC cells·mm−312.8±6.514±50.23
 Platelets cells·mm−3222±71212±1130.63
PCO2 mmHg43±944±110.54
Right heart catheterisation data
 mPAP mmHg23±827±110.028
 PCWP mmHg8±47.5±50.46
 Cardiac index L·min−1·m−23±2.72.7±0.70.53
 PVR WU3.4±2.64.4±2.90.11
Oesophageal pH and manometry data
 Number of total reflux episodes#36±2530±260.34
 Time with pH <4# %16±2517±240.96
 GORD score#10±159±130.76

Data are presented as n, mean±sd or n (%), unless otherwise stated. BMI: body mass index; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; DLCO: diffusing capacity of the lung for carbon monoxide; WBC: white blood cells; PCO2: partial pressure of CO2; mPAP: mean pulmonary artery pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; WU: Wood units; GORD: gastro-oesophageal reflux disease. #: based on 24-h oesophageal multichannel intraluminal impedance and pH monitoring: eight patients from the no AE-IPF and 10 patients from the AE-IPF groups did not complete the studies and were excluded from the GORD data analysis; : not statistically significant when excluding patients evaluated and listed during AE-IPF.