Baseline characteristics and pre-evaluation data at time of lung transplantation listing for patients without acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) before lung transplantation and patients with AE-IPF before lung transplantation
| No AE-IPF group | AE-IPF group | p-value | |
| Subjects | 52 | 37 | |
| Baseline characteristics | |||
| Age | 66±7 | 67±5 | 0.42 |
| Male/female | 39/13 | 22/15 | 0.17 |
| BMI kg·m−2 | 28±4 | 28±4 | 0.28 |
| Comorbidities and smoking history | |||
| Diabetes mellitus | 11 (21) | 12 (32) | 0.33 |
| Hypertension | 18 (35) | 21 (57) | 0.051 |
| Coronary artery disease | 25 (48) | 22 (59) | 0.39 |
| Congestive heart failure (systolic) | 0 | 1 (3) | 0.42 |
| Smoking history | 38 (73) | 25 (68) | 0.65 |
| Ever-smoker pack-years | 23±11 | 16±29 | 0.42 |
| Pulmonary function tests | |||
| FEV1/FVC | 84±7 | 86±8 | 0.17 |
| FEV1 % pred | 52±15 | 50±15 | 0.42 |
| FVC % pred | 47±13 | 43±12 | 0.2 |
| TLC % pred | 48±9 | 46±9 | 0.41 |
| RV % pred | 44±15 | 33±10 | 0.004 |
| DLCO % pred | 28±11 | 24±10 | 0.17 |
| Baseline oxygen saturation % | 90±6 | 88±6 | 0.09 |
| 6-min walk distance m | 254±99 | 218±74 | 0.08 |
| Lowest oxygen saturation % | 83±13 | 81±6 | 0.61 |
| Blood tests | |||
| Creatinine mg·dL−1 | 0.91±0.2 | 0.82±0.3 | 0.096 |
| Albumin g·dL−1 | 3.4±0.53 | 2.95±0.54 | 0.0002¶ |
| WBC cells·mm−3 | 12.8±6.5 | 14±5 | 0.23 |
| Platelets cells·mm−3 | 222±71 | 212±113 | 0.63 |
| PCO2 mmHg | 43±9 | 44±11 | 0.54 |
| Right heart catheterisation data | |||
| mPAP mmHg | 23±8 | 27±11 | 0.028¶ |
| PCWP mmHg | 8±4 | 7.5±5 | 0.46 |
| Cardiac index L·min−1·m−2 | 3±2.7 | 2.7±0.7 | 0.53 |
| PVR WU | 3.4±2.6 | 4.4±2.9 | 0.11 |
| Oesophageal pH and manometry data | |||
| Number of total reflux episodes# | 36±25 | 30±26 | 0.34 |
| Time with pH <4# % | 16±25 | 17±24 | 0.96 |
| GORD score# | 10±15 | 9±13 | 0.76 |
Data are presented as n, mean±sd or n (%), unless otherwise stated. BMI: body mass index; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; DLCO: diffusing capacity of the lung for carbon monoxide; WBC: white blood cells; PCO2: partial pressure of CO2; mPAP: mean pulmonary artery pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; WU: Wood units; GORD: gastro-oesophageal reflux disease. #: based on 24-h oesophageal multichannel intraluminal impedance and pH monitoring: eight patients from the no AE-IPF and 10 patients from the AE-IPF groups did not complete the studies and were excluded from the GORD data analysis; ¶: not statistically significant when excluding patients evaluated and listed during AE-IPF.