TABLE 2

Absolute forced vital capacity (FVC) decline and hazard ratios (HR) for developing acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) based on FVC decline (compared to <5% absolute decline)

No AE-IPFAE-IPFAE-IPF HR (95% CI)p-value
Subjects#4822
Absolute FVC decline
 <5% pred26 (54)4 (18)Reference
 5–10% pred12 (25)5 (23)3.2 (0.77–13.5)0.11
 10–15% pred4 (8)5 (23)5.6 (1.33–23.8)0.019
 >15% pred6 (13)8 (34)7.3 (1.91–27.6)0.004

Data are presented as n or n (%), unless otherwise stated. #: data were not available for four and 15 patients from the no-AE-IPF and AE-IPF groups, respectively.