Main characteristics of patients (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.7) and controls (FEV1/FVC≥0.7) included in the ECLIPSE study
| Patients | Controls | p-value | |
| Subjects n | 119 | 124 | |
| Demographics and exposure history | |||
| Age years | 47.3±2.7 | 45.7±3.0 | <0.001 |
| Males | 61% | 52% | 0.162 |
| Body mass index kg·m−2 | 26.5±6.9 | 26.1±4.6 | 0.650 |
| Cumulative smoking exposure pack-years | 34.5±17.0 | 24.7±11.7 | <0.001 |
| Current smokers | 38% | 23% | 0.014 |
| Family history and early-life events | |||
| Familiar asthma | 24% | 19% | 0.342 |
| Familiar bronchitis | 34% | 15% | 0.001 |
| Familiar emphysema | 29% | 8% | <0.001 |
| Familiar hypertension | 49% | 48% | 1 |
| Symptoms | |||
| mMRC score ≥2 | 13% | 1% | 0.001 |
| Previous treatments and use of healthcare resources | |||
| Oral Corticosteroid use | 2% | 0% | 0.460 |
| Number of exacerbations | 0.7± 0.9 | NA | |
| Physiology | |||
| FEV1/FVC (post-bd) % | 49.0± 11.8 | 80.1±4.9 | <0.001 |
| FEV1 (post-bd) % ref. | 49.0± 18.2 | 103.9±10.8 | <0.001 |
| FVC (post-bd) % ref. | 82.5± 22.1 | 112.8±12.6 | <0.001 |
| Total lung capacity % ref. | 114.0± 17.5 | 102.79±11.4 | <0.001 |
| 6MWD test | |||
| Distance walked m | 425.6±137.7 | NA | |
| Imaging | |||
| Presence of CT emphysema n (%) | 60% | 8% | <0.001 |
| Biomarkers | |||
| Basophils (%) | 0.33± 0.23 | 0.32± 0.24 | 0.527 |
| Eosinophils (%) | 2.6± 2.1 | 2.55± 1.58 | 0.464 |
| Haematocrit | 0.44±0.04 | 0.43± 0.04 | 0.009 |
| Lymphocytes (%) | 28.04± 8.61 | 30.22± 7.11 | 0.024 |
| Monocytes (%) | 5.96± 2.49 | 5.76± 2.23 | 0.682 |
| Segmented neutrophils (%) | 63.06± 9.52 | 61.15± 8.29 | 0.102 |
| Total neutrophils (total ANC) | 5.23± 2.2 | 4.71± 1.95 | 0.050 |
| Total neutrophils (%) | 63.06± 9.52 | 61.15± 8.29 | 0.102 |
| White blood cells ×109/L | 8.11± 2.49 | 7.56± 2.37 | 0.057 |
Results are presented as mean±sd or proportion. p-values <0.05 are highlighted in bold text. mMRC: modified Medical Research Council scale; post-bd: post-bronchodilator; % ref.: % of reference value; 6MWD: 6-min walk test; CT: computed tomography; ANC: total absolute neutrophil count.