Risk of hypersensitivity pneumonitis combining home visit and interview data
| Risk factor | OR (95% CI) | p-value |
| Model 1. All home visits participants: cases (n=118) and referents (n=106) | ||
| FEV1% and FVC% both <80% predicted | 2.66 (1.25–5.62) | 0.0107 |
| Exhaled NO ppb | 1.03 (1.00–1.07) | 0.0249 |
| Alveolar NO ppb | 1.02 (0.95–1.10) | 0.5368 |
| Elevated serum avian antibody | 0.90 (0.17–4.69) | 0.8959 |
| Elevated serum mould precipitins | 2.03 (0.59–6.90) | 0.2576 |
| HSCRP >90th percentile | 1.69 (0.44–3.13) | 0.7539 |
| CC16 >90th percentile | 3.07 (1.21–7.83) | 0.0184 |
| sST2 >90th percentile | 1.67 (0.70–3.95) | 0.2465 |
| Any occupational exposure | 2.83 (1.44–5.53) | 0.0024 |
| Bird (nonoccupational) | 2.78 (1.08–7.17) | 0.0341 |
| Mould (nonoccupational) | 1.43 (0.70–2.93) | 0.3214 |
| Model 2. IHCDS cases (n=83) cases and referents (n=106) | ||
| FEV1% and FVC% both <80% predicted | 2.43 (1.08–5.47) | 0.0320 |
| Exhaled NO ppb | 1.03 (1.00–1.06) | 0.0510 |
| Alveolar NO ppb | 1.02 (0.95–1.09) | 0.6631 |
| Elevated serum mould precipitins | 1.54 (0.37–6.36) | 0.5499 |
| Elevated serum avian antibody | 1.00 (0.18–5.38) | 0.9966 |
| HSCRP >90th percentile | 1.14 (0.39–3.31) | 0.8051 |
| CC16 >90th percentile | 2.91 (1.03–8.26) | 0.0440 |
| sST2 >90th percentile | 1.14 (0.43–3.02) | 0.7907 |
| Any occupational exposure | 3.53 (1.72–7.23) | 0.0006 |
| Bird (nonoccupational) | 2.81 (1.09–7.27) | 0.0326 |
| Mould (nonoccupational) | 0.96 (0.42–2.18) | 0.9199 |
| Model 3. UCSF cases (n=35) and IHCDS controls (n=106) | ||
| FEV1% and FVC% both <80% predicted | 3.67 (1.15–11.74) | 0.0284 |
| Exhaled NO ppb | 1.04 (0.99–1.09) | 0.0846 |
| Alveolar NO ppb | 1.06 (0.99–1.17) | 0.1921 |
| Elevated serum avian antibody | 0.65 (0.04–9.59) | 0.7518 |
| Elevated serum mould precipitins | 3.97 (0.87–17.82) | 0.0754 |
| HSCRP >90th percentile | 1.07 (0.25–4.58) | 0.9923 |
| CC16 >90th percentile | 4.26 (1.27–16.11) | 0.0327 |
| sST2 >90th percentile | 3.86 (1.11–13.43) | 0.0343 |
| Any occupational exposure | 1.13 (0.37–3.42) | 0.8336 |
| Bird (nonoccupational) | 1.78 (0.35–9.13) | 0.4876 |
| Mould (nonoccupational) | 3.69 (1.25–10.93) | 0.0184 |
FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; NO: nitric oxide; HSCRP: high-sensitivity C-reactive protein; CC16: club cell secretory protein; sST2: soluble suppression of tumorigenicity 2; IHCDS: Integrated Health Care Delivery System; UCSF: University of California San Francisco.