TABLE 1

Outcome of salbutamol dose delivered via metered-dose inhaler (MDI) and different MDI–spacer combinations in 4 L volume of inhalation (assuming adult inhalation volume)

MDI or MDI/accessory deviceNatureEmitted dose %Dose deposited in spacer %
MDI only86.8 ± 5.1NA
Aerochamber mouthpieceAntistatic71.6 ± 4.416.8 ± 3.30
Aerochamber maskAntistatic69.7 ± 5.418.9 ± 4.9
Able spacer mouthpieceAntistatic64.2 ± 6.923.2 ± 4.3
Able spacer maskAntistatic61.2 ± 6.624.1 ± 4.9
Tips-haler mouthpieceAntistatic53.6 ± 7.234.4 ± 7.4
Tips-haler maskAntistatic51.3 ± 4.734.6 ± 5.8
Dolphin chamber mouthpieceNon-antistatic31.9 ± 5.456 ± 4.7
Dolphin chamber maskNon-antistatic30.5 ± 5.655.2 ± 9.7
Dolphin chamber washNon-antistatic49.7 ± 6.4NA
Drink bottle mouthpieceNon-antistatic35.3 ± 6.950.2 ± 4.3
Drink bottle washNon-antistatic51.2 ± 7.1NA

Data are presented as mean±sd. NA: not applicable.