Regression analysis of perinatal parameters on outcomes in adult BPD

FIO2 36w (B (p))−3.2 (0.29)−6.4 (0.053)−4.1 (0.023)−2.4 (0.36)3.7 (0.86)
Prenatal dexa (B (p))−0.64 (0.24)0.19 (0.74)0.56 (0.069)−0.77 (0.097)4.2 (0.27)
Birthweight g (B (p))−0.0023 (0.0091)−0.0015 (0.089)0.0097 (0.043)0.0014 (0.075)0.0065 (0.28)
PIPmax (B (p))0.028 (0.51)0.028 (0.53)0.0020 (0.93)−0.020 (0.55)−0.093 (0.74)
R2 adjusted (adjusted p-values of likelihood ratio test)0.20 (0.046)0.16 (0.081)0.17 (0.057)0.13 (0.10)−0.057 (0.67)

Multiple linear regression analyses were used to determine whether neonatal parameters correlated with outcomes at adult age within the BPD group. None of the dependent variables at adulthood reached a significance level, set at p<0.0025 by Bonferroni correction. zFEV1/FVC, zFEV1, zFVC, are z-scores for adult lung function outcomes with GLI-references and zDLCO with European Community of Coal and Steel references. Prenatal dexa: ante partum dexamethasone administered to mothers (yes=1, no=0). BPD: bronchopulmonary dysplasia; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; SMS: standard mass score for lung density; SGRQ: St. George's Respiratory Questionnaire; FIO2 36w: fractional inspired oxygen concentration in ambient air at post-conceptional age of 36 weeks; PIPmax: maximum positive inspiratory pressure during mechanical ventilation in cmH2O; DLCO: diffusing capacity of the lung for carbon monoxide.